Table 4

Univariate analysis for risk factors for Day 14 and Day 30 mortalities, and unfavorable outcomes at end of teicoplanin therapy
Variables Day 14 mortality Day 30 mortality Unfavorable outcome
OR p value OR p value OR p value
Age 1.01 0.3749 1.02 0.0138 1.02 0.0628
Sex (male to female) 0.67 0.3025 0.84 0.5748 1.06 0.8281
Charlson comorbidity index 1.10 0.7972 2.73 0.0974 1.04 0.4988
Onset in ICU 1.08 0.8307 2.71 0.1147 1.44 0.1587
Presence of metastatic foci 1.79 0.1337 1.48 0.2079 1.21 0.5225
Endocarditis 0.95 0.9338 2.17 0.8592 2.16 0.0430
Septic shock 3.08 0.0083 18.11 <0.0001 8.44 <0.0001
Primary bacteremia 0.90 0.7724 0.69 0.1781 0.73 0.2215
Cardiovascular diseases 1.04 0.9336 1.63 0.1452 1.54 0.1503
Respiratory diseases 0.71 0.4507 1.01 0.9698 0.92 0.7860
Neurologic diseases 0.60 0.2247 0.79 0.4384 0.77 0.3388
Gastrointestinal tract diseases 0.42 0.0415 0.48 0.0157 0.90 0.6976
Hepatobiliary diseases 0.62 0.3419 0.56 0.1292 0.65 0.1934
Genitourinary tract diseases 0.98 0.9619 1.52 0.1338 1.31 0.2996
Endocrinologic diseases 1.07 0.8595 1.43 0.2029 1.47 0.1290
Malignancies 0.78 0.5217 0.94 0.8247 1.01 0.9860
Autoimmune diseases 4.27 0.0044 1.98 0.1543 0.72 0.5218
Immunosuppression 1.45 0.3246 1.39 0.2654 1.19 0.5264
Abnormal white blood cell count
  < 4,000/μL 1.26 0.6380 0.71 0.4259 0.79 0.5671
  > 12,000/μL 0.49 0.0851 0.59 0.0798 0.89 0.6658
Anemia 1.22 0.5959 1.11 0.7155 1.38 0.2135
Thrombocytopenia 4.20 0.0003 2.43 0.0017 1.35 0.2357
Hypoalbuminemia 3.40 0.2427 1.12 0.8368 2.09 0.1375
Abnormal liver function with clinical significance 6.94 0.0214 3.04 0.1815 1.85 0.4593
Abnormal renal function 1.34 0.4481 2.06 0.0168 1.58 0.0856
C-reactive protein 1.00 0.9269 1.00 0.9232 1.04 0.0166
Without effective treatment within 48 hours 0.77 0.5428 1.20 0.5698 0.87 0.6310
Adequate loading dose 0.932 0.8488 0.76 0.3335 0.93 0.7845
Combination therapy 1.46 0.3666 0.76 0.4481 0.60 0.1322
Teicoplanin MIC by broth dilution 0.76 0.5983 1.65 0.1712 1.02 0.9451
Teicoplanin MIC by Etest 0.90 0.7976 1.00 0.9949 1.15 0.6451
Sequence types (ST5, ST239 compared to other types)
  ST5 0.664 0.4758 0.61 0.2047 0.76 0.4346
  ST239 1.54 0.2992 0.85 0.6109 1.02 0.9531

Wang et al.

Wang et al. BMC Infectious Diseases 2013 13:182   doi:10.1186/1471-2334-13-182

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