Table 1

Demographic, clinical data and primary outcome parameters
Year 2005 2006 2007 2008 2009 P§ p-value trend#
Patient (n) 38 31 27 27 18
Gender (m/f) 20/18 16/15 14/13 18/9 11/7 0.728 0.289
Age (years)* 68.6 ±15.9 73.8 ±9.5 68.0 ±13.5 67.5 ±13.9 65.4 ±11.6 0.196 0.125
SAPS II * 45.0 ±17.7 43.4 ±17.9 42.5 ±19.8 44.3 ±19.0 37.0 ±10.9 0.603 0.177
Apache II * 20.0 ±8.8 20.5 ±8.8 18.2 ±8.7 17.9 ±9.7 15.6 ±7.2 0.327 0.041
Effective cost weight * 14.8 ±13.6 13.3 ±11.4 17.2 ±14.0 14.5 ±13.6 19.2±18.5 0.623 0.256
Average change per year
Mean 95% CI p
ICU stay (days) 26.0 ± 1.9 19.5 ± 2.2 18.5 ± 2.3 16.3 ± 2.3 15.8 ± 2.8 −2.7 −4.1 to −1.3 < 0.001
Ventilation (hours) 571.4 ± 41.5 455.0 ± 47.3 404.1 ± 49.2 362.0 ± 49.9 467.9 ± 60.9 −42.0 −72.6 to −11.4 0.008
Antibiotic use (days) 14.3 ± 1.2 12.0 ± 1.3 13.8 ± 1.4 12.1 ± 1.4 9.0 ± 1.7 −1.0 −1.9 to −0.2 0.02
Antibiotic costs (EUR/patient) 407.6 ± 57.2 420.7 ± 66.7 426.6 ± 67.7 393.2 ± 68.5 373.9 ± 83.7 −14.3 −55.7 to 27.1 0.495
ICU reinfection rate (proportion) 0.31 ± 0.07 0.37 ± 0.08 0.13 ± 0.06 0.12 ± 0.06 0.08 ± 0.06 −35.1% −53.9% to −8.5% 0.014
28-day mortality (proportion) 0.54 ± 0.06 0.51 ± 0.07 0.55 ± 0.08 0.48 ± 0.07 0.34 ± 0.01 −22.4% −44.3% to 8.1% 0.133

Demographic and clinical data:

* Mean ± standard deviation.

§ F test of ANOVA (continuous characteristic) or Wald chi square test (categorical characteristic) of logistic regression model.

# Linear polynomial contrasts (continuous characteristic) or Cochran-Armitage trend tests (categorical characteristic).

SAPS II, Simplified Acute Physiology Score II.

APACHE II, Acute Physiology And Chronic Health Evaluation Score II.

Primary outcome parameters:

Adjusted Means ± standard error and average yearly change of outcome parameters, with 95 confidence limits (CI) and p values of trend tests from ANCOVA or logistic regression models with covariates gender, age, SAPS II, APACHE II and effective cost weight.

Hohn et al.

Hohn et al. BMC Infectious Diseases 2013 13:158   doi:10.1186/1471-2334-13-158

Open Data