Table 1 |
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Demographic, clinical data and primary outcome parameters | ||||||||
Year | 2005 | 2006 | 2007 | 2008 | 2009 | P^{§} | p-value trend^{#} | |
Patient (n) | 38 | 31 | 27 | 27 | 18 | |||
Gender (m/f) | 20/18 | 16/15 | 14/13 | 18/9 | 11/7 | 0.728 | 0.289 | |
Age (years)* | 68.6 ±15.9 | 73.8 ±9.5 | 68.0 ±13.5 | 67.5 ±13.9 | 65.4 ±11.6 | 0.196 | 0.125 | |
SAPS II * | 45.0 ±17.7 | 43.4 ±17.9 | 42.5 ±19.8 | 44.3 ±19.0 | 37.0 ±10.9 | 0.603 | 0.177 | |
Apache II * | 20.0 ±8.8 | 20.5 ±8.8 | 18.2 ±8.7 | 17.9 ±9.7 | 15.6 ±7.2 | 0.327 | 0.041 | |
Effective cost weight * | 14.8 ±13.6 | 13.3 ±11.4 | 17.2 ±14.0 | 14.5 ±13.6 | 19.2±18.5 | 0.623 | 0.256 | |
Average change per year | ||||||||
Mean | 95% CI | p | ||||||
ICU stay (days) | 26.0 ± 1.9 | 19.5 ± 2.2 | 18.5 ± 2.3 | 16.3 ± 2.3 | 15.8 ± 2.8 | −2.7 | −4.1 to −1.3 | < 0.001 |
Ventilation (hours) | 571.4 ± 41.5 | 455.0 ± 47.3 | 404.1 ± 49.2 | 362.0 ± 49.9 | 467.9 ± 60.9 | −42.0 | −72.6 to −11.4 | 0.008 |
Antibiotic use (days) | 14.3 ± 1.2 | 12.0 ± 1.3 | 13.8 ± 1.4 | 12.1 ± 1.4 | 9.0 ± 1.7 | −1.0 | −1.9 to −0.2 | 0.02 |
Antibiotic costs (EUR/patient) | 407.6 ± 57.2 | 420.7 ± 66.7 | 426.6 ± 67.7 | 393.2 ± 68.5 | 373.9 ± 83.7 | −14.3 | −55.7 to 27.1 | 0.495 |
ICU reinfection rate (proportion) | 0.31 ± 0.07 | 0.37 ± 0.08 | 0.13 ± 0.06 | 0.12 ± 0.06 | 0.08 ± 0.06 | −35.1% | −53.9% to −8.5% | 0.014 |
28-day mortality (proportion) | 0.54 ± 0.06 | 0.51 ± 0.07 | 0.55 ± 0.08 | 0.48 ± 0.07 | 0.34 ± 0.01 | −22.4% | −44.3% to 8.1% | 0.133 |
Demographic and clinical data:
* Mean ± standard deviation.
^{§} F test of ANOVA (continuous characteristic) or Wald chi square test (categorical characteristic) of logistic regression model.
^{#} Linear polynomial contrasts (continuous characteristic) or Cochran-Armitage trend tests (categorical characteristic).
SAPS II, Simplified Acute Physiology Score II.
APACHE II, Acute Physiology And Chronic Health Evaluation Score II.
Primary outcome parameters:
Adjusted Means ± standard error and average yearly change of outcome parameters, with 95 confidence limits (CI) and p values of trend tests from ANCOVA or logistic regression models with covariates gender, age, SAPS II, APACHE II and effective cost weight.
Hohn et al.
Hohn et al. BMC Infectious Diseases 2013 13:158 doi:10.1186/1471-2334-13-158