Table 2

All possible combinations of the six clinical and laboratory variables, along with the respective linear correlation coefficient (R2) and its significance (P value), when correlated with CDI cure for patients in the 003 trial database with available values for all analyzed variables; n=515
R2 P value R2 P value
Single variables Four variables
Ag 0.91 0.195 Ag, Tr, Te, S * 0.92 <0.001
Tr 1.0 N/A Ag, Tr, Te, Al 0.79 0.001
Te 0.95 0.147 Ag, Tr, Te, L 0.89 <0.001
L 1.0 0.025 Ag, Tr, Al, S 0.82 <0.001
Al 0.99 0.070 Ag, Tr, L, S 0.25 0.175
S 0.47 0.518 Ag, Tr, L, Al 0.75 0.001
Ag, Te, Al, S * 0.95 <0.001
Two variables Ag, Te, L, S 0.78 0.008
Ag, Tr 0.78 0.048 Ag, Te, L, Al * 0.91 <0.001
Ag, Te 0.84 0.011 Ag, L, Al, S 0.87 0.001
Ag, S 0.49 0.191 Tr, Te, Al, S 0.79 0.001
Ag, Al * 0.97 0.003 Tr, Te, L, S 0.82 0.001
Ag, L 0.68 0.087 Tr, Te, L, Al 0.86 0.003
Tr, Te 0.79 0.044 Tr, L, Al, S 0.65 0.016
Tr, S 0.70 0.077 Te, L, Al, S * 0.91 <0.001
Tr, Al 0.84 0.030
Tr, L 0.26 0.375 Five variables
Te, S 0.06 0.702 Ag, Tr, Te, Al, S 0.80 <0.001
Te, Al * 0.92 0.002 Ag, Tr, Te, L, S 0.82 0.002
Te, L 0.89 0.058 Ag, Tr, S, L, Al ** 0.95 <0.001
Al, S 0.90 0.015 Ag, Te, L, Al, S 0.78 0.001
L, S 0.63 0.108 Ag, Tr, Te, L, Al 0.86 <0.001
L, Al * 0.94 0.006 Tr, Te, L, Al, S 0.79 0.001
Three variables Six variables
Ag, Tr, Te 0.85 0.003 Ag, Tr, Te, L, Al, S 0.70 0.001
Ag, Tr, S 0.86 0.003
Ag, Tr, Al 0.86 0.003
Ag, Tr, L * 0.96 <0.001
Ag, Te, S * 0.98 0.001
Ag, Te, Al 0.83 0.002
Ag, Te, L * 0.90 0.001
Ag, Al, S 0.86 0.002
Ag, L, S 0.10 0.482
Ag, L, Al 0.810 0.002
Tr, Te, S 0.82 0.005
Tr, Te, Al; 0.82 0.002
Tr, Te, L 0.71 0.036
Tr, Al, S 0.84 0.004
Tr, L, S 0.00 0.975
Tr, L, Al 0.49 0.081
Te, Al, S 0.17 0.366
Te, L, S 0.84 0.029
Te, L, Al * 0.95 <0.001
L, Al, S 0.79 0.003

All combinations meeting the pre-set “acceptable” criteria (R2 ≥ 0.9 and P ≤ 0.01) are marked with an asterisk (*), and the single combination among this latter group which was composed of the largest number of variables is marked with a double asterisk (**) as the optimal scoring system.

Ag = age; Tr = treatment with systemic antibiotics; Te = temperature; L = leukocyte count (total); Al = serum albumin; S = serum creatinine as a measure of renal function.

CDI: Clostridium difficile infection.

N/A: not applicable.

Miller et al.

Miller et al. BMC Infectious Diseases 2013 13:148   doi:10.1186/1471-2334-13-148

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