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Open Access Research article

Survey of human papillomavirus types and their vertical transmission in pregnant women

Ying Hong123*, Shu-Qin Li1, Ya-Li Hu1 and Zhi-Qun Wang1

Author affiliations

1 Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China

2 Nanjing Medical University, Nanjing 210008, China

3 Nanjing University of Chinese Medicine, 210008, Nanjing, China

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Citation and License

BMC Infectious Diseases 2013, 13:109  doi:10.1186/1471-2334-13-109

Published: 27 February 2013

Abstract

Background

The prevalence, genotypes, and vertical transmission characteristics of human papillomavirus (HPV) among pregnant women from Nanjing, China was investigated.

Methods

Cervical cells were collected from healthy pregnant women (n = 3139; stage of gestation, 24.6 ± 2.1 weeks) for cytological evaluation and determination of HPV infection status. Exfoliated oral and genital cells were collected from neonates (<1-day-old, n = 233) whose mothers were positive for HPV DNA. We used HPV Gene Chip technology with 23 HPV genotype probes to conduct our analysis.

Results

Overall prevalence of HPV DNA among pregnant women was 13.4% (422/3139). The most frequently detected HPV genotypes were HPV-16 (29.6%, 125/422), -18 (14.7%, 62/422), and -58 (14.2%, 60/422). The rate of concordance for HPV DNA in maternal-neonatal pairs was 23.6% (55/233), with HPV type-specific concordance occurring in 26 cases. A higher prevalence of HPV DNA was apparent in female neonates compared with males (17.7 vs. 11.6%).

Conclusions

The prevalence of cervical HPV DNA in pregnant women from Nanjing was low, with vertical transmission rates slightly higher. From our findings, we concluded that there was efficient vertical transmission of three HPV genotypes, with HPV-16 the most prevalent type in pregnant women and newborn babies.

Keywords:
Human papillomavirus; Pregnancy; Vertical transmission