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Open Access Highly Accessed Research article

Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya, 2007-2010

Jamal A Ahmed17*, Mark A Katz1, Eric Auko2, M Kariuki Njenga1, Michelle Weinberg3, Bryan K Kapella3, Heather Burke1, Raymond Nyoka1, Anthony Gichangi1, Lilian W Waiboci1, Abdirahman Mahamud2, Mohamed Qassim4, Babu Swai4, Burton Wagacha4, David Mutonga5, Margaret Nguhi6, Robert F Breiman1 and Rachel B Eidex1

Author Affiliations

1 US Centers for Disease Control and Prevention, Nairobi, Kenya

2 Kenya Medical Research Institute, Nairobi, Kenya

3 US Centers for Disease Control and Prevention, Atlanta, GA, USA

4 United Nations High Commissioner for Refugees, Nairobi, Kenya

5 Ministry of Public Health and Sanitation, Nairobi, Kenya

6 International Rescue Committee, Nairobi, Kenya

7 KEMRI/CDC, Mbagathi Road off Mbagathi Way, KEMRI Compound, P.O. Box 606, Nairobi 00621, Kenya

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BMC Infectious Diseases 2012, 12:7  doi:10.1186/1471-2334-12-7

Published: 17 January 2012

Abstract

Background

Refugees are at risk for poor outcomes from acute respiratory infections (ARI) because of overcrowding, suboptimal living conditions, and malnutrition. We implemented surveillance for respiratory viruses in Dadaab and Kakuma refugee camps in Kenya to characterize their role in the epidemiology of ARI among refugees.

Methods

From 1 September 2007 through 31 August 2010, we obtained nasopharyngeal (NP) and oropharyngeal (OP) specimens from patients with influenza-like illness (ILI) or severe acute respiratory infections (SARI) and tested them by RT-PCR for adenovirus (AdV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), parainfluenza viruses (PIV), and influenza A and B viruses. Definitions for ILI and SARI were adapted from those of the World Health Organization. Proportions of cases associated with viral aetiology were calculated by camp and by clinical case definition. In addition, for children < 5 years only, crude estimates of rates due to SARI per 1000 were obtained.

Results

We tested specimens from 1815 ILI and 4449 SARI patients (median age = 1 year). Proportion positive for virus were AdV, 21.7%; RSV, 12.5%; hMPV, 5.7%; PIV, 9.4%; influenza A, 9.7%; and influenza B, 2.6%; 49.8% were positive for at least one virus. The annual rate of SARI hospitalisation for 2007-2010 was 57 per 1000 children per year. Virus-positive hospitalisation rates were 14 for AdV; 9 for RSV; 6 for PIV; 4 for hMPV; 5 for influenza A; and 1 for influenza B. The rate of SARI hospitalisation was highest in children < 1 year old (156 per 1000 child-years). The ratio of rates for children < 1 year and 1 to < 5 years old was 3.7:1 for AdV, 5.5:1 for RSV, 4.4:1 for PIV, 5.1:1 for hMPV, 3.2:1 for influenza A, and 2.2:1 for influenza B. While SARI hospitalisation rates peaked from November to February in Dadaab, no distinct seasonality was observed in Kakuma.

Conclusions

Respiratory viral infections, particularly RSV and AdV, were associated with high rates of illness and make up a substantial portion of respiratory infection in these two refugee settings.