Table 1

M.tb target antigens used for T cell stimulation

M.tb target protein

ID

Biology


Cyclopropane fatty acyl phospholipid synthase

Rv0447c

Involved in lipid formation and synthesis of long fatty acids, resistance to (oxidative) stress and survival


Mycobacterium bovis mycocerosic acid synthase gene (mas)

Rv2940c

(mas) multifunctional enzyme that catalyzes the synthesis of very long chain multiple methyl branched fatty acids called mycocerosic acids present in slow-growing pathogenic mycobacteria, major mycobacterial cell wall complex


PPE family proteins

Rv3347c

Accounts for about 10% of the genomic M.tb coding capacity. Form a source for antigenic variation among different M.tb strains


Rv1917c (p)

Induces functional maturation of dendritic cells through an integrated cross talk between PI3K-MAPK and NF-κB signaling cascades and facilitates a Th2 phenotype


PE_PGRS 11 family proteins

Rv0754 (p) Rv0978c (p)

Cell wall associated protein, induces activation and maturation of human dendritic cells as well as secretion of key proinflammatory cytokines


Probable molybdopterin-guanine dinucleotide biosynthesis protein

Rv2453c

Involved in metabolism and respiration, associated with non replicating bacteria


Secreted antigen 85A and 85B

Hypotheticall cell wall protein

Rv3804c (85A) (p)

Rv1886c (85B)

(both as peptides and protein)

Rv0959

Mycolyl transferase activity. Responsible for the high affinity of mycobacteria to fibronectin

Cell- wall associated protein


Probable lipoprotein LPRJ

Rv1690

Contains possible signal sequence and a prokaryotic membrane lipoprotein lipid attachment site


Secreted ESAT-6 like protein ESXH (TB10.3)

ESAT-6

Rv3019

Rv3875 (p)

M.tb pathogenicity


Possible glycosyl transferase

Rv2957c, Rv2958c Rv2962c

cellular metabolism and lipid formation, contributes to M.tb survival in macrophages


Possible hemolysin -like protein

Rv1085c

virulence and adaption


Probable isocitrate dehydrogenase

Rv0066c

cellular metabolism


Low molecular weight protein antigen 7 esxH

Rv0288 (TB10.4) peptides and protein

bacterial virulence


List of M.tb target antigens used for T-cell stimulation. Proteins are designated with (p) unless stated otherwise

Ahmed et al. BMC Infectious Diseases 2012 12:41   doi:10.1186/1471-2334-12-41

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