Open Access Research article

Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus

Raija K Ahmed1, Zoyia Rohava2, Kithiganahalli N Balaji3, Sven E Hoffner1, Hans Gaines1, Isabelle Magalhaes4, Alimuddin Zumla5, Alena Skrahina2 and Markus J Maeurer46*

Author Affiliations

1 Swedish Institute for Communicable Disease Control (SMI), Solna, Sweden

2 Republican Scientific and Practical Center for Pulmonology and Tuberculosis, Minsk, Belarus

3 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

4 Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Nobelsväg 16, SE 17182 Solna, Sweden

5 Department of Infection, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK

6 Center for allogeneic stem cell transplantation (CAST), Karolinska Hospital, Stockholm, Sweden

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BMC Infectious Diseases 2012, 12:41  doi:10.1186/1471-2334-12-41

Published: 15 February 2012

Additional files

Additional file 1:

Table S1. Detailed information concerning TB patients (clinic, chest-X-ray, bacteriology).

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Additional file 2:

Table S2. Detailed listing of synthetic peptides used for T-cell reactivity testing using the wholeblood assay (WBA).

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Additional file 3:

Table S3. P values of IFN-γ responses in PBMCs.

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Additional file 4:

Figure S1. PBMCs from NHPs before (-) and after (+) BCG vaccination were tested for IL-2 cytokine production in CD4+ and CD8+ T-cells. Increased intracellular IL-2 production in response to Rv2947/2958 or to Rv0477c peptide stimulation in a standard 6 hr intracellular cytokine assay.

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