Table 5

Distribution of A2694T PfATPase 6 polymorphism in drug sensitive groups
Drug Profils N Strains with polymorphism PfATPase 6 A2694T
A T MIX p
CQ Resistant (IC50>100 nM) 20 14 (70.0%) 5 (25.0%) 1 (5.0%) 0.45
Sensitive (IC50<100 nM) 26 20 (76.9%) 5 (19.2%) 1 (3.8%)
MDAQ Resistant (IC50 ≥ 60 nM) 24 17 (69.2%) 6 (26.9%) 1 (3.8%) 0.6
Sensitive (IC50 < 60 nM) 22 17 (80.0%) 4 (15.0%) 1 (5.0%)
MF Resistant (IC50>20 nM) 11 7 (63.6%) 3 (27.3%) 1 (9.1%) 0.4
Sensitive (IC50<20 nM) 35 27 (77.1%) 7 (20.0%) 1 (2.9%)
DHA Reduced susceptibility (IC50 ≥ 10 nM) 11 8 (72.7%) 3 (27.3%) 0 (0.0%) 0.4
Sensitive (IC50<10 nM) 35 26 (74.3%) 7 (20.0%) 2 (5.71%)

Zatra et al.

Zatra et al. BMC Infectious Diseases 2012 12:307   doi:10.1186/1471-2334-12-307

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