Table 3

Chronological selected blood indices for patient 1 and 5
Week since starting HAART Alb Total Bil ALT ALP GGT Hb WCC plt lactate INR
Patient 1
−2 First visit to ARV clinic 23 5 13 152 73 7.4 6.5 394 n/a
0 26 11 20 131 89 8.0 5.5 314 n/a
+2 Presents with jaundice 2 weeks post HAART 20 88* 127 833 429 7.0 3.1 803 2.9 1.3
+4 Starts 14 days prednisolone 17 62 99 1310 673 7.0 2.9 736 n/a 1.0
+8 Clinically improved 24 22 49 667 330 7.9 3.9 448 n/a 1.0
Patient 5
−2 First visit to ARV clinic 22 18 34 119 35 11.3 5.4 364 n/a n/a
0 After 2 weeks TB treatment starts HAART 24 21 45 133 57 9.3 4.4 682 n/a n/a
+2 Has been found to have jaundice 10 days post HAART; TB treatment stopped 21 56* 60 115 99 n/a n/a n/a 2.7 1.3
+3 With resolving jaundice and clinical deterioration TB treatment restarted 26 26 48 138 93 9.5 2.6 460 2.6 1.2
+4 Return of jaundice and liver biopsy suggests DILI – TB treatment stopped 21 97 67 187 148 9.2 2.7 424 1.6 1.4

* > 85% conjugated bilirubin.

Alb albumin in g/L, Bil total total bilirubin μmol/L, ALT alanine aminotransteraseiu/L, ALP alkaline phosphatase iu/L, GGT Gamma-glutamyltranspeptidaseiu/L., Hb haemoglobin in g/dL; WCC = white cell count (total) x109/L; plt = platelets x109/L; lactate is measured in mmol/L; INR = international normalised ratio.

Barr and Ramdial

Barr and Ramdial BMC Infectious Diseases 2012 12:257   doi:10.1186/1471-2334-12-257

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