Table 2

Multivariate analysis of variables associated with mortality in patients with S. aureus bacteremia
Variable Unadjusted Adjusted
OR (95% CI) P OR (95% CI) P
Demographic characteristics
Age
0-9 4.2 (1.7, 10.3) 0.002 5.1 (1.7, 15.3) 0.004
10-19 1.3 (0.4, 4.3) 0.682 2.4 (0.6, 10.0) 0.213
20-29 (reference) 1.0 1.0
30-39 2.4 (1.0, 6.0) 0.059 2.7 (0.9, 8.4) 0.078
40-49 4.8 (2.1, 11.2) <0.001 7.1 (2.5, 19.9) <0.001
50-59 7.1 (3.1, 16.4) <0.001 8.5 (3.1, 23.6) <0.001
60-69 10.6 (4.7, 24.1) <0.001 14.8 (5.4, 40.6) <0.001
70-79 18.8 (8.3, 42.6) <0.001 23.8 (8.7, 65.1) <0.001
80-89 29.3 (12.9, 66.3) <0.001 38.1 (13.9, 104) <0.001
90+ 46.2 (19.8, 108) <0.001 54.4 (19.1, 154) <0.001
Sex
Female 1.0
Male 1.0 (0.9, 1.2) 0.838
Ethnicity
Indigenous 1.0
Asian 2.7 (1.7, 4.2) <0.001
Caucasian 3.1 (2.2, 4.3) <0.001
Polynesian 1.7 (0.9, 3.4) 0.131
Other 1.7 (1.0, 3.0) 0.052
IRSAD quintile
1 1.0
2 1.3 (1.0, 1.7) 0.033
3 1.3 (1.0, 1.6) 0.050
4 1.2 (1.0, 1.5) 0.091
5 1.3 (1.0, 1.6) 0.026
Risk factors and Acquisition
Dialysis
No 1.0
Yes 0.7 (0.5, 0.8) <0.001
IDU
No 1.0
Yes 0.3 (0.2, 0.4) <0.001
Acquisition
Community onset 1.0
Community onset HCA 2.1 (1.7, 2.5) <0.001 1.4 (1.1,1.7) 0.011
Nosocomial 2.4 (2.0, 2.9) <0.001 1.5 (1.2,1.9) 0.001
Microbiology and antibiotics
Susceptibility
MSSA 1.0
cMRSA 1.3 (1.0, 1.6) 0.025
eMRSA 2.0 (1.7, 2.3) <0.001
Antibiotic treatment
β-lactam 1.0
Glycopeptide 2.0 (1.7, 2.3) <0.001 1.5 (1.3, 1.8) <0.001
Other 2.1 (1.6, 2.8) <0.001 1.6 (1.2, 2.2) 0.002
Clinical infection
Primary focus
SSTI 1.0 1.0
Device with 2° infection 1.8 (1.2, 2.7) 0.003 1.9 (1.3, 2.9) 0.003
Device with no 2° infection 0.8 (0.7, 1.0) 0.118 0.9 (0.7, 1.2) 0.600
IE Left sided 1.5 (1.0, 2.1) 0.025 2.2 (1.5, 3.2) <0.001
IE Right sided 0.6 (0.3, 1.1) 0.092 1.4 (0.7, 3.0) 0.308
No focus 1.9 (1.6, 2.4) <0.001 1.4 (1.1, 1.9) 0.011
Bone/joint 0.6 (0.4, 0.8) <0.001 0.8 (0.6, 1.1) 0.228
Respiratory 3.7 (2.9, 4.8) <0.001 3.6 (2.7, 4.8) <0.001
Sepsis 4.4 (3.5, 5.5) <0.001 4.0 (3.1, 5.3) <0.001
ICU
No 1.0 1.0
Yes 1.8 (1.5, 2.1) <0.001 2.2 (1.8, 2.7) <0.001

Note. Adjusted odds ratios and P values are only displayed if that variable was significant in the final multivariate model. OR, odds ratio; CI, confidence interval; IRSAD, Index of Relative Socio-economic Advantage or Disadvantage; HCA, healthcare-associated; MSSA, methicillin-susceptible S. aureus; cMRSA, community-associated methicillin-resistant S. aureus; eMRSA, epidemic MRSA; SSTI, skin and soft tissue infection; IE, infective endocarditis; ICU, intensive care unit.

Tong et al.

Tong et al. BMC Infectious Diseases 2012 12:249   doi:10.1186/1471-2334-12-249

Open Data