Table 3 |
|||||||||
| Summary of articles meetingthe inclusion criteria | |||||||||
| Author & Publication Year(Reference) | Study Population | Age [years] | # Subjects (# Titers) | Days Post- Exposure | Neut. % | DENV1 strains | DENV2 strains | DENV3 strains | DENV4 strains |
| Natural Exposure Studies | |||||||||
| Russell et al. 1967 [19] | Thailand, USA | children, adults | 7 (28) | 17-28 | 50 | -- | -- | -- | -- |
| Sukhavachana et al. 1969 [20] | -- | -- | 2 (16) | 7, 14 | 50 | Hawaii | New Guinea C | H87 | H241 |
| Scott et al. 1972 [21] | Puerto Rico | -- | 3 (11) | 11-20 | 50 | Hawaii | PR-109 | H87 | 23751 |
| Russell and McCown 1972 [22] | Puerto Rico, Tahiti | -- | 5 (30) | 21 | 50 | n/a | n/a | H87, 21153, PR-6, PR-38, J-1007, Tahiti-4 | n/a |
| Halstead 1974 [23]* | USA | adults | 9 (36) | 15341-17532 | 50 | 16007 | 16681 | 16562 | 4328-S |
| Papaevangelou and Halstead 1977 [24]* | Greece | adults | 45 (180) | 16436 | 50 | 16007 | 16681 | 16562 | 4328S |
| Fujita and Yoshida 1979 [25] | Japan | 45-74 | 9 (36) | 12419 | 50 | Mochizuki, Hawaii | Trinidad 1751 | H87 | H241 |
| Scott et al. 1976 [26] | Thailand | children | 6 (48) | 3-67 | 50 | -- | -- | -- | -- |
| van Peenen et al. 1978 [27] | Indonesia | 1-18 | 4 (32) | 7, 14 | -- | -- | -- | -- | -- |
| Okuno et al. 1980 [28]* | Thailand | 1-13 | 20 (160) | 1-13 | 50 | Hawaii | New Guinea B | H87 | H241 |
| Fukunaga et al. 1983 [29]* | Japan | 28-55 | 9 (36) | 2-13 | 50 | Hawaii | New Guinea B | H87 | H241 |
| Okuno et al. 1983 [30] | Japan | adults | 11 (51) | 1826-14610 | -- | Hawaii, Mochizuki | New Guinea B | H87 | H241 |
| Sangkawibha et al. 1984 [15]* | Thailand | 1-8 | 8 (60) | 0-17 | 50 | 16007 | 16681 | 16562 | 4328-S |
| Morens et al. 1985 [31] | Puerto Rico | -- | 24 (267) | 0-70 | 50 & 70 | CV.1636 / 77 | PR-159 | PR-6 | n/a |
| Rosen 1986 [32]* | Greece, Pacific Islands, USA | 42-60 | 68 (268) | 7-16436 | 90 | Hawaii | New Guinea C | H87 | H241 |
| Kliks et al. 1989 [33]* | Thailand | children | 10 (40) | 0 | 50 | -- | D80-616 | -- | -- |
| Kuno et al. 1993 [34] | Puerto Rico | 4-50 | 9 (79) | 0-83 | 50 | -- | -- | -- | -- |
| Graham et al. 1999 [35]* | Indonesia | 4-9 | 17 (131) | 0, 10-361 | 70 | 16007 | 16681 | 16562 | 1009 |
| Yamada et al. 2003 [36] | Japan | -- | 37 (71) | 2-44 | 50 | -- | -- | -- | -- |
| Alvarez et al. 2006 [37]* | Cuba | -- | 43 (371) | 3-21, 517-834 | 50 | Angola | A15/81, I348600 | 116/00 | Dominica / 814669 |
| Alvarez et al. 2008 [38]* | Cuba | -- | 20 (140) | 515 | 50 | n/a | n/a | 116/00, 118/00, 140/00, 167/01, 557/01, 21/02, Puerto Rico | n/a |
| Lai et al. 2008 [39]* | Taiwan | -- | 7 (32) | 7-14 | 70 | Hawaii | New Guinea C | H87 | H241 |
| da Silva-Nunes et al. 2008 [40] | Brazil | 5-90 | 20 (120) | 0, 274 | 50 | -- | -- | -- | n/a |
| Crill et al. 2009 [41]* | Taiwan, Puerto Rico | -- | 12 (48) | 6-18 | 80 | 56BC94 / 95 | 16681 | 116RC1396 | H241 |
| Vaccination Studies | |||||||||
| Summers et al. 1984 [42]* | USA | -- | 8 (16) | 30, 180 | 50 | n/a | PR-159 | n/a | n/a |
| Rabablert et al. 2000 [43]* | Thailand | 18-35 | 8 (64) | 0, 60 | -- | 16007 | 16681 | 16562 | 1036 |
| Rothman et al. 2001 [44] | USA | -- | 6 (48) | 60, 180 | 80 | Hawaii | New Guinea C | CH53489 | Dominica / 814669 |
| Kanesa-Thasan et al. 2003 [45]* | USA | 18-49 | 20 (397) | 0, 28, 60, 120, 180 | 50 | -- | -- | -- | -- |
| Guy et al. 2004 [46] | Thailand | 4-14 | 16 (128) | 273, 2009 | 50 | 16007 | 16681 | 16562 | 1036 |
| Kitchener et al. 2006 [47] | Australia | 21-39 | 10 (40) | 42 | 50 | -- | -- | -- | -- |
| Vasilakis et al. 2008 [18]*^ | USA, unknown location | 18-50 | 61 (719) | 42 vacc, 16 infect | 80 | OBS7690, P72-1244 | 16681, 1349, IQT1950, 1328, P8-1407, DakArA510, DakArA1247, DakArA2022 | FSP-032 | H241, P75-125 |
| Sun et al. 2009 [48] | USA | 18-45 | 71 (704) | 28, 180, 208 | 50 | 45AZ5 | S16803 | CH53489 | 341750 |
“Neut. %” indicates neutralization percentage; “DENV#” indicates dengue virus serotype; “—” indicates unreported data; “n/a” indicates serotype was not tested, ^ indicates article contains titers from vaccination and infection studies, * indicates article was included in the pooled analysis.
Rainwater-Lovett et al. BMC Infectious Diseases 2012 12:233 doi:10.1186/1471-2334-12-233
