Table 3

Summary of articles meetingthe inclusion criteria
Author & Publication Year(Reference) Study Population Age [years] # Subjects (# Titers) Days Post- Exposure Neut. % DENV1 strains DENV2 strains DENV3 strains DENV4 strains
Natural Exposure Studies
Russell et al. 1967 [19] Thailand, USA children, adults 7 (28) 17-28 50 -- -- -- --
Sukhavachana et al. 1969 [20] -- -- 2 (16) 7, 14 50 Hawaii New Guinea C H87 H241
Scott et al. 1972 [21] Puerto Rico -- 3 (11) 11-20 50 Hawaii PR-109 H87 23751
Russell and McCown 1972 [22] Puerto Rico, Tahiti -- 5 (30) 21 50 n/a n/a H87, 21153, PR-6, PR-38, J-1007, Tahiti-4 n/a
Halstead 1974 [23]* USA adults 9 (36) 15341-17532 50 16007 16681 16562 4328-S
Papaevangelou and Halstead 1977 [24]* Greece adults 45 (180) 16436 50 16007 16681 16562 4328S
Fujita and Yoshida 1979 [25] Japan 45-74 9 (36) 12419 50 Mochizuki, Hawaii Trinidad 1751 H87 H241
Scott et al. 1976 [26] Thailand children 6 (48) 3-67 50 -- -- -- --
van Peenen et al. 1978 [27] Indonesia 1-18 4 (32) 7, 14 -- -- -- -- --
Okuno et al. 1980 [28]* Thailand 1-13 20 (160) 1-13 50 Hawaii New Guinea B H87 H241
Fukunaga et al. 1983 [29]* Japan 28-55 9 (36) 2-13 50 Hawaii New Guinea B H87 H241
Okuno et al. 1983 [30] Japan adults 11 (51) 1826-14610 -- Hawaii, Mochizuki New Guinea B H87 H241
Sangkawibha et al. 1984 [15]* Thailand 1-8 8 (60) 0-17 50 16007 16681 16562 4328-S
Morens et al. 1985 [31] Puerto Rico -- 24 (267) 0-70 50 & 70 CV.1636 / 77 PR-159 PR-6 n/a
Rosen 1986 [32]* Greece, Pacific Islands, USA 42-60 68 (268) 7-16436 90 Hawaii New Guinea C H87 H241
Kliks et al. 1989 [33]* Thailand children 10 (40) 0 50 -- D80-616 -- --
Kuno et al. 1993 [34] Puerto Rico 4-50 9 (79) 0-83 50 -- -- -- --
Graham et al. 1999 [35]* Indonesia 4-9 17 (131) 0, 10-361 70 16007 16681 16562 1009
Yamada et al. 2003 [36] Japan -- 37 (71) 2-44 50 -- -- -- --
Alvarez et al. 2006 [37]* Cuba -- 43 (371) 3-21, 517-834 50 Angola A15/81, I348600 116/00 Dominica / 814669
Alvarez et al. 2008 [38]* Cuba -- 20 (140) 515 50 n/a n/a 116/00, 118/00, 140/00, 167/01, 557/01, 21/02, Puerto Rico n/a
Lai et al. 2008 [39]* Taiwan -- 7 (32) 7-14 70 Hawaii New Guinea C H87 H241
da Silva-Nunes et al. 2008 [40] Brazil 5-90 20 (120) 0, 274 50 -- -- -- n/a
Crill et al. 2009 [41]* Taiwan, Puerto Rico -- 12 (48) 6-18 80 56BC94 / 95 16681 116RC1396 H241
Vaccination Studies
Summers et al. 1984 [42]* USA -- 8 (16) 30, 180 50 n/a PR-159 n/a n/a
Rabablert et al. 2000 [43]* Thailand 18-35 8 (64) 0, 60 -- 16007 16681 16562 1036
Rothman et al. 2001 [44] USA -- 6 (48) 60, 180 80 Hawaii New Guinea C CH53489 Dominica / 814669
Kanesa-Thasan et al. 2003 [45]* USA 18-49 20 (397) 0, 28, 60, 120, 180 50 -- -- -- --
Guy et al. 2004 [46] Thailand 4-14 16 (128) 273, 2009 50 16007 16681 16562 1036
Kitchener et al. 2006 [47] Australia 21-39 10 (40) 42 50 -- -- -- --
Vasilakis et al. 2008 [18]*^ USA, unknown location 18-50 61 (719) 42 vacc, 16 infect 80 OBS7690, P72-1244 16681, 1349, IQT1950, 1328, P8-1407, DakArA510, DakArA1247, DakArA2022 FSP-032 H241, P75-125
Sun et al. 2009 [48] USA 18-45 71 (704) 28, 180, 208 50 45AZ5 S16803 CH53489 341750

“Neut. %” indicates neutralization percentage; “DENV#” indicates dengue virus serotype; “—” indicates unreported data; “n/a” indicates serotype was not tested, ^ indicates article contains titers from vaccination and infection studies, * indicates article was included in the pooled analysis.

Rainwater-Lovett et al.

Rainwater-Lovett et al. BMC Infectious Diseases 2012 12:233   doi:10.1186/1471-2334-12-233

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