Open Access Highly Accessed Research article

Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects

Valentina Li Vecchi1, Maurizio Soresi1*, Lydia Giannitrapani1, Giovanni Mazzola2, Sara La Sala3, Fabio Tramuto3, Giuseppe Caruso4, Claudia Colomba3, Pasquale Mansueto1, Simona Madonia3, Giuseppe Montalto1 and Paola Di Carlo3

Author Affiliations

1 Dipartimento di Medicina Interna, Università di Palermo, Via del Vespro 141, Palermo, I-90127, Italy

2 Dipartimento di Medicina Clinica e delle Patologie Emergenti, Azienda Ospedaliera Universitaria Policlinico “Paolo Giaccone” di Palermo, Via del Vespro 133, Palermo, I-90127, Italy

3 Dipartimento di Scienze per la Promozione della Salute, Università di Palermo, Via del Vespro 133, Palermo, I-90127, Italy

4 Dipartimento di Biotecnologie Mediche e Medicina Legale, Università di Palermo, Via del Vespro 133, Palermo, I-90127, Italy

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BMC Infectious Diseases 2012, 12:192  doi:10.1186/1471-2334-12-192

Published: 15 August 2012

Abstract

Background

Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects.

We assessed the prevalence of low BMD in HIV-infected and uninfected subjects and analyzed the effects of calcium intake, lifestyle and HIV-related risk factors on BMD.

Methods

One hundred and twelve HIV-infected subjects were consecutively enrolled. Seventy- six HIV-uninfected subjects matched for age and sex were enrolled as the control group. The HIV-subjects were interviewed about lifestyle habits and completed a weekly food-frequency questionnaire to estimate calcium intake. HIV-RNA, CD4+ T-cell count and data on antiretroviral therapy were also recorded. Both biochemical bone turnover markers and BMD, assessed by dual-energy radiographic absorptiometry (DXA) were recorded in the HIV-cases and controls. We also calculated the 10-year fracture risks using the WHO FRAX equation.

Results

Osteoporosis prevalence was significantly higher in the HIV-cases than controls (p < 0.05). BMI values were positively correlated with BMD (p < 0.05). Vitamin D levels were lower in the HIV-subjects (p < 0.02). No correlation was found with daily calcium intake.

BMI values were significantly correlated with dairy intake quartiles (p < 0.003). In HIV-subjects, the mean of FRAX score was 1.2 % for hip and 4.7 % for major osteoporotic fractures. On multivariate analysis of the lumbar spine DXA T-score, age (p < 0.005) and HIV/hepatitis C virus co-infection (p < 0.0001) were negatively correlated with BMD, while yogurt intake was a protective predictor of BMD (p < 0.05). In the femur DXA T-score, age (p < 0.01), nadir CD4 + T-cell count < 200 cells/μL (p < 0.05) and drug addiction ( p < 0.0001) were negatively correlated with BMD.

Conclusions

Among the foods rich in calcium, yogurt was a protective predictor of BMD in HIV-subjects. HIV/HCV co-infection, nadir CD4 + T-cell count < 200 cells/μL and drug addiction were independent predictors of severe BMD. Promoting behavioral changes in food intake and lifestyle, aimed at the primary prevention of bone disease in the chronically-infected subjects seems to be essential for implementing medical intervention in these cases.

Keywords:
HIV; Osteopenia; Osteoporosis; Dairy intake; Bone mineral density