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Open Access Highly Accessed Research article

Infection rate of Eperythrozoon spp. in Chinese population: a systematic review and meta-analysis since the first Chinese case reported in 1991

De-Sheng Huang12*, Peng Guan1, Wei Wu1, Tie-Feng Shen3, He-Ling Liu4, Shuang Cao1 and Hao Zhou1

Author Affiliations

1 Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, China

2 Department of Mathematics, College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China

3 Huludao Municipal Center for Disease Control and Prevention, Huludao, 125000, China

4 Department of Biomedical Engineering, China Medical University, Shenyang, 110001, China

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BMC Infectious Diseases 2012, 12:171  doi:10.1186/1471-2334-12-171

Published: 31 July 2012

Abstract

Background

Eperythrozoonosis is an important animal health problem worldwide, it not only has a major impact on the economic viability, but also makes a significant impact on public health issues. The present systemic review intends to collate all relevant published data to assess the burden of Eperythrozoon infection in Chinese population and discuss the implications of these findings for public health policy.

Methods

A meta-analysis was conducted to review the published studies that reported Eperythrozoon spp. in Chinese population. Inclusion criteria comprised of the use of microscopic venous blood smear examination for Eperythrozoon detection and a detailed description of sampling techniques.

Results

Twenty-four cross-sectional studies with 52,433 participants and 14,951 positive cases, within the range of China mainland, were included in the present analysis. The infection rate of Eperythrozoon varied from 0 to 97.29% with geographical and seasonal variations, people with mild infection intensity contributed the major part (68.93%). The infection rates were highest in the children and adolescents group, significantly increased risk of Eperythrozoon infection was found among herdsmen.

Conclusions

The current study raises awareness about the human eperythrozoonosis in China, which is a newly emerging zoonosis. The majority of Eperythrozoon infection intensity was asymptomatic mild infection. The infection rate of Eperythrozoon in Chinese population varied by geographical region, season, age and occupation. These factors need to be considered when conducting health education campaigns and comparing the surveillance results from different studies.

Keywords:
Eperythrozoon; Infection; Meta-analysis