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Open Access Research article

The seroepidemiology of Immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study

Qi Zhang1, Huizhen Zheng2*, Meizhen Liu2, Ke Han2, Jun Shu2, Chenggang Wu2, Ning Xu2, Qiushui He3 and Huiming Luo4

Author Affiliations

1 National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Diseases Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China

2 Center for Disease Control and Prevention of Guangdong Province, Guangzhou 501300, People's Republic of China

3 Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Turku and Department of Pediatrics, Turku University Hospital, Turku 20520, Finland

4 National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, People's Republic of China

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BMC Infectious Diseases 2012, 12:138  doi:10.1186/1471-2334-12-138

Published: 20 June 2012

Abstract

Background

Pertussis is a reported vaccine-preventable respiratory disease in China. Because the routine laboratory methods for diagnosis are not in use, the reported cases are mainly in infants with classical paroxysmal cough and the true incidence related to pertussis is most likely under estimated. In China, however, few studies have attempted to address this issue. The purpose of this cross sectional study was to estimate the incidence rates using the method of sero-epidemiology of immunoglobulin (Ig) G antibodies against pertussis toxin (PT) among healthy populations in China.

Methods

Blood samples were obtained from 1313 healthy individuals aged 0 to 95 years in Guangdong province of China throughout September 2010. Serum IgG antibodies against PT were determined by commercial ELISA kits. Subjects with concentration of anti-PT IgG higher than 30 IU/mL were indicated to have recent Bordetella pertussis infection, if they have not received a booster dose of pertussis vaccine within one year.

Results

Of the 1313 study subjects, 117 (8.91%) were found to have anti-PT antibodies higher than 30 IU/mL. The estimated incidence of recent infection was thus 9395 per 100,000 for individuals older than 7 years. Peaks of the estimated incidence rate of recent infection were found to be 11561 per 100,000 in age group of 41–50 years and 11428 per 100,000 in the group aged 13–19 years.

Conclusions

Our study indicated that B.pertussis infections are considerablely common, particularly in adolescents and adults in China. The study also stresses the importance of laboratory diagnosis for pertussis and employment of booster dose of pertussis vaccine in adolescents and adults in this country.

Keywords:
Pertussis; Cross-sectional study; Sero-epidemiology; Anti-PT IgG; China