Graph showing the sensitivity of a commercially available enzyme-linked immunosorbent assay (ELISA) to detect lipoarabinomannan (LAM) within urine samples to diagnose tuberculosis (TB) in a cohort of patients accessing antiretroviral treatment (ART) in a South African township.
The sensitivity (%) of sputum microscopy and the LAM ELISA are shown individually and combined (either positive) compared with a gold standard of automated liquid culture of two sputum samples. Data are stratified by CD4 cell count (cells/μL) and show that the sensitivity of the LAM ELISA was substantially greater in the patients with the lowest CD4 cell counts. Figure reproduced from Lawn et al. 2011  and data originally from Lawn et al. 2009 .
Lawn BMC Infectious Diseases 2012 12:103 doi:10.1186/1471-2334-12-103