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Open Access Highly Accessed Software

The GLEaMviz computational tool, a publicly available software to explore realistic epidemic spreading scenarios at the global scale

Wouter Van den Broeck1, Corrado Gioannini1*, Bruno Gonçalves23, Marco Quaggiotto14, Vittoria Colizza567* and Alessandro Vespignani237*

Author Affiliations

1 Computational Epidemiology Laboratory, Institute for Scientific Interchange (ISI), Turin, Italy

2 Center for Complex Networks and Systems Research, School of Informatics and Computing, Indiana University, Bloomington, IN 47408, USA

3 Pervasive Technology Institute, Indiana University, Bloomington, IN 47404, USA

4 Department of Industrial Design, Arts, Communication and Fashion (INDACO), Politecnico di Milano, Milan, Italy

5 INSERM, U707, Paris F-75012, France

6 UPMC Université Paris 06, Faculté de Médecine Pierre et Marie Curie, UMR S 707, Paris F75012, France

7 Institute for Scientific Interchange (ISI), Turin, Italy

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BMC Infectious Diseases 2011, 11:37  doi:10.1186/1471-2334-11-37

Published: 2 February 2011

Abstract

Background

Computational models play an increasingly important role in the assessment and control of public health crises, as demonstrated during the 2009 H1N1 influenza pandemic. Much research has been done in recent years in the development of sophisticated data-driven models for realistic computer-based simulations of infectious disease spreading. However, only a few computational tools are presently available for assessing scenarios, predicting epidemic evolutions, and managing health emergencies that can benefit a broad audience of users including policy makers and health institutions.

Results

We present "GLEaMviz", a publicly available software system that simulates the spread of emerging human-to-human infectious diseases across the world. The GLEaMviz tool comprises three components: the client application, the proxy middleware, and the simulation engine. The latter two components constitute the GLEaMviz server. The simulation engine leverages on the Global Epidemic and Mobility (GLEaM) framework, a stochastic computational scheme that integrates worldwide high-resolution demographic and mobility data to simulate disease spread on the global scale. The GLEaMviz design aims at maximizing flexibility in defining the disease compartmental model and configuring the simulation scenario; it allows the user to set a variety of parameters including: compartment-specific features, transition values, and environmental effects. The output is a dynamic map and a corresponding set of charts that quantitatively describe the geo-temporal evolution of the disease. The software is designed as a client-server system. The multi-platform client, which can be installed on the user's local machine, is used to set up simulations that will be executed on the server, thus avoiding specific requirements for large computational capabilities on the user side.

Conclusions

The user-friendly graphical interface of the GLEaMviz tool, along with its high level of detail and the realism of its embedded modeling approach, opens up the platform to simulate realistic epidemic scenarios. These features make the GLEaMviz computational tool a convenient teaching/training tool as well as a first step toward the development of a computational tool aimed at facilitating the use and exploitation of computational models for the policy making and scenario analysis of infectious disease outbreaks.