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Open Access Highly Accessed Correspondence

Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned

Matthias Borchert129*, Imaam Mutyaba3, Maria D Van Kerkhove24, Julius Lutwama5, Henry Luwaga103, Geoffrey Bisoborwa3, John Turyagaruka113, Patricia Pirard6, Nestor Ndayimirije127, Paul Roddy8 and Patrick Van Der Stuyft1

Author Affiliations

1 Unit of Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium

2 Infectious Disease Epidemiology Unit, London School of Hygiene & Tropical Medicine, Keppel Street, Bloomsbury WC1E 7HT, London, UK

3 District Directorate of Health Services, Masindi, Uganda

4 MRC Centre for Outbreak Analysis and Modelling, Imperial College, London, UK

5 Uganda Virus Research Institute, Entebbe, Uganda

6 Médecin Sans Frontières, Brussels, Belgium

7 World Health Organisation African Region, Kampala, Uganda

8 Médecin Sans Frontières, Barcelona, Spain

9 Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, Spandauer Damm 130, D-14050, Berlin, Germany

10 National Tuberculosis and Leprosy Programme, Ministry of Health, 2 Lourdel Road, Wandegeya, P.O. Box 16069, Kampala, Uganda

11 Masindi District Health Office, Box 67, Masindi, Uganda

12 World Health Organization Liberia, Monrovia, Liberia

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BMC Infectious Diseases 2011, 11:357  doi:10.1186/1471-2334-11-357

Published: 28 December 2011

Abstract

Background

Ebola haemorrhagic fever (EHF) is infamous for its high case-fatality proportion (CFP) and the ease with which it spreads among contacts of the diseased. We describe the course of the EHF outbreak in Masindi, Uganda, in the year 2000, and report on response activities.

Methods

We analysed surveillance records, hospital statistics, and our own observations during response activities. We used Fisher's exact tests for differences in proportions, t-tests for differences in means, and logistic regression for multivariable analysis.

Results

The response to the outbreak consisted of surveillance, case management, logistics and public mobilisation. Twenty-six EHF cases (24 laboratory confirmed, two probable) occurred between October 21st and December 22nd, 2000. CFP was 69% (18/26). Nosocomial transmission to the index case occurred in Lacor hospital in Gulu, outside the Ebola ward. After returning home to Masindi district the index case became the origin of a transmission chain within her own extended family (18 further cases), from index family members to health care workers (HCWs, 6 cases), and from HCWs to their household contacts (1 case). Five out of six occupational cases of EHF in HCWs occurred after the introduction of barrier nursing, probably due to breaches of barrier nursing principles. CFP was initially very high (76%) but decreased (20%) due to better case management after reinforcing the response team. The mobilisation of the community for the response efforts was challenging at the beginning, when fear, panic and mistrust had to be countered by the response team.

Conclusions

Large scale transmission in the community beyond the index family was prevented by early case identification and isolation as well as quarantine imposed by the community. The high number of occupational EHF after implementing barrier nursing points at the need to strengthen training and supervision of local HCWs. The difference in CFP before and after reinforcing the response team together with observations on the ward suggest a critical role for intensive supportive treatment. Collecting high quality clinical data is a priority for future outbreaks in order to identify the best possible FHF treatment regime under field conditions.