Table 1

Patient outcome for 6 aetiological categories of Acute Encephalitis Syndrome.

Suspected viral aetiology

Non-viral aetiology


Outcome

AES of suspected viral aetiology

Confirmed JE

AES of unknown viral aetiology

Non-JE

JE Status Unknown

Bacterial (n = 37)* P.f. (n = 1)


Lp status

+Lp

    -Lp

    Both

+Lp

    -Lp

    Both

+Lp

    -Lp

    Both

+Lp

    -Lp

    Both

+Lp

    -Lp

    Both

+Lp

    -Lp

    Both

Patient No.

145

35

180

42

8

50

103

27

130

44

12

56

59

15

74

38

3

41

Good

100

(69)

19

(54)

119

(63)

22

(52)

3

(37.5)

25

(50)

78

(76)

16

(60)

94

(72)

22

(73)

8

(66)

40

(71)

46

(78)

8

(53)

54

(73)

33

(87)

2(

66)

35

(85)

Bad

45

(31)§

16

(46)

61

(37)§

20

(48)‡¶

5

(62.5)

25

(50)‡¶∆

25

(24)

11

(40)

36

(28)

12

(27)

4

(33)

16

(29)¶∆

13

(22)

7

(47)

20

(27)

5

(13)§‡

1

(33)

6

(15)§‡

Neurol.

Sequelae

37

(25)

7

(20)

44

(24)

16

(38)

3

(37.5)

19

(38)

21

(20)

4

(15)

25

(19)

12

(27)

1

(8)

13

(23)

9

(15)

3

(20)

12

(16)

3

(8)

0

(0)

3

(7)

Died

8

(5)

9

(26)

17

(9)

4

(9.5)

2

(25)

6

(12)

4

(4)

7

(26)

11

(8)

0

(0)

3

(25)

3

(6)

4

(7)

4

(27)

8

(11)

2

(5)

1

(33)

3

(7)


Outcome at hospital discharge is presented for 2 main aetiological categories of Acute Encephalitis Syndrome (AES); suspected viral and non-viral. Based on JE serology, AES of suspected viral aetiology was split into Confirmed JE and Unknown viral aetiology. The latter group was sub-categorised into Non-JE and JE status unknown. AES of non-viral aetiology included Bacterial and Plasmodium falciparum (P.f.) infection. Within each category, patients were split into 3 groups based on availability of LP results; +Lp, those with LP results; -Lp, those without; Both, combining both +Lp and -Lp patients. Patients without LP results were assigned to an AES group based on their discharge diagnosis and JE serological results. Patients with a bad outcome were sub-classified into those with neurological sequelae at discharge or those that died. Number with (%) is presented. Significance was tested via Fisher's Exact test.

* 38/40 patients with AES of Non-viral aetiology had an outcome recorded at discharge.

§ Significant difference between suspected viral and non-viral patients (P = 0.039 and P = 0.022 respectively for +Lp and Both groups).

Significant difference between JE and non-viral patients (P = 0.001 and P < 0.001 respectively for +Lp and Both groups).

Significant difference between JE and Unknown viral patients (P = 0.01 and P = 0.008 respectively for +Lp and Both).

Significant difference between JE and Non-JE patients in the Both group (P = 0.029).

A similar trend was observed for outcome between JE and Non-JE patients in the +Lp group (P = 0.074).

A higher frequency of death was consistently observed among -Lp patients compared to +Lp patients in each AES category.

Rayamajhi et al. BMC Infectious Diseases 2011 11:294   doi:10.1186/1471-2334-11-294

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