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Open Access Highly Accessed Research article

Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons 2007/2008 and 2008/2009

Susanna Esposito1*, Claudio Giuseppe Molteni1, Cristina Daleno1, Antonia Valzano1, Emilio Fossali1, Liviana Da Dalt2, Valerio Cecinati3, Eugenia Bruzzese4, Raffaella Giacchino5, Carlo Giaquinto2, Angie Lackenby6 and Nicola Principi1

Author Affiliations

1 Department of Maternal and Pediatric Sciences, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

2 Pediatric Department, University of Padua, Padua, Italy

3 Department of Biomedicine of Evolutive Age, University of Bari, Bari, Italy

4 Pediatric Department, Federico II University, Naples, Italy

5 Infectious Disease Unit, IRCCS Ospedale Giannina Gaslini, Genoa, Italy

6 Health Protection Agency, London, UK

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BMC Infectious Diseases 2011, 11:271  doi:10.1186/1471-2334-11-271

Published: 12 October 2011

Abstract

Background

There are few and debated data regarding possible differences in the clinical presentations of influenza A/H1N1, A/H3N2 and B viruses in children. This study evaluates the clinical presentation and socio-economic impact of laboratory-confirmed influenza A/H1N1, A/H3N2 or B infection in children attending an Emergency Room because of influenza-like illness.

Methods

Among the 4,726 children involved, 662 had influenza A (143 A/H1N1 and 519 A/H3N2) and 239 influenza B infection detected by means of real-time polymerase chain reaction. Upon enrolment, systematic recordings were made of the patients' demographic characteristics and medical history using standardised written questionnaires. The medical history of the children was re-evaluated 5-7 days after enrolment and until the resolution of their illness by means of interviews and a clinical examination by trained investigators using standardised questionnaires. During this evaluation, information was also obtained regarding illnesses and related morbidity among households.

Results

Children infected with influenza A/H1N1 were significantly younger (mean age, 2.3 yrs) than children infected with influenza A/H3N2 (mean age, 4.7 yrs; p < 0.05)) or with influenza B (mean age, 5.2 yrs; p < 0.05). Adjusted for age and sex, children with influenza A/H3N2 in comparison with those infected by either A/H1N1 or with B influenza virus were more frequently affected by fever (p < 0.05) and lower respiratory tract involvement (p < 0.05), showed a worse clinical outcome (p < 0.05), required greater drug use (p < 0.05), and suffered a worse socio-economic impact (p < 0.05). Adjusted for age and sex, children with influenza B in comparison with those infected by A/H1N1 influenza virus had significantly higher hospitalization rates (p < 0.05), the households with a disease similar to that of the infected child (p < 0.05) and the need for additional household medical visits (p < 0.05).

Conclusions

Disease due to influenza A/H3N2 viral subtype is significantly more severe than that due to influenza A/H1N1 subtype and influenza B virus, which indicates that the characteristics of the different viral types and subtypes should be adequately considered by health authorities when planning preventive and therapeutic measures.

Keywords:
A/H1N1 influenza virus; children; influenza; pediatrics; viral types; viral subtypes