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Open Access Highly Accessed Research article

Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

Yan-Wei Zhong1, Jin Li1, Hong-Bin Song2, Zhong-Ping Duan3, Yi Dong1, Xiao-Yan Xing1, Xiao-Dong Li1, Mei-Lei Gu1, Yu-Kun Han1, Shi-Shu Zhu1* and Hong-Fei Zhang1*

Author Affiliations

1 Pediatric Liver Disease Therapy and Research Center, Beijing 302 Hospital, Beijing, China

2 Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China

3 Beijing You'an Hospital, Capital Medical University, Beijing, China

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BMC Infectious Diseases 2011, 11:262  doi:10.1186/1471-2334-11-262

Published: 30 September 2011

Abstract

Background

The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.

Methods

Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.

Results

Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.

Conclusions

The pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.

Keywords:
hepatitis B virus; genotypes/subgenoytpes; drug mutation; hepatic inflammation; fibrosis; pediatric patients