Table 1

Characteristics of 226 Patients Receiving Fluoroquinolone (FQ) Antibiotics

Characteristic

Unnecessary

(n = 70)

Necessary

(n = 157)

P Value


Age in years-median (IQR)

65 (49, 80)

59 (45, 72)

0.045

Males

30 (43)

70 (45)

0.81

Hospitalized in previous 12 months

48 (69)

101 (64)

0.58

Antibiotics in previous 3 months

29 (41)

83 (53)

0.11

FQ antibiotics in previous 3 months

11 (16)

33 (21)

0.35

Long-term care resident

20 (29)

36 (23)

0.38

Comorbidities

Diabetes

23 (33)

53 (34)

0.89

Cancer

9 (13)

30 (19)

0.25

Chronic neurological condition

17 (24)

28 (18)

0.26

Dementia

12 (17)

16 (10)

0.14

Service First Prescribing FQs

Emergency Department

22 (31)

55 (35)

0.60

Medicine

25 (36)

68 (43)

0.28

Surgery

6 (9)

21 (13)

0.38

Family Practice

8 (11)

6 (4)

0.04

Rehabilitation Medicine

9 (13)

3 (2)

0.002

Obstetrics/Gynecology

0 (0)

4 (3)

0.31

Indication

Treatment

68 (97)

150 (96)

0.73

Prophylaxis

2 (3)

7 (4)

Regimen

FQ as monotherapy

46 (66)

51 (32)

< 0.001

FQ in combination with other antimicrobials

24 (34)

106 (68)

Syndrome

Urinary

36 (51)

28 (18)

< 0.001

Pulmonary

2 (3)

50 (32)

< 0.001

Upper respiratory tract

4 (6)

9 (6)

1.000

Bacteremia

3 (4)

7 (4)

1.000

Fever or sepsis syndrome

3 (4)

11 (7)

0.56

Diarrhea

2 (3)

3 (2)

0.65

Intra-abdominal

2 (3)

20 (13)

0.03

Skin and soft tissue

4 (6)

7 (5)

0.74

Non-infectious condition

11 (16)

18 (11)

0.39

Other

3 (4)

4 (3)

0.68


Interquartile range (IQR). Data are number of regimens (percentage of regimen category) unless otherwise indicated. Categorical data were assessed using Pearson Chi-square test or Fisher's exact test; Fisher's exact test was used for categorical data when the expected value for any given cell was less than 10.

Werner et al. BMC Infectious Diseases 2011 11:187   doi:10.1186/1471-2334-11-187

Open Data