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Open Access Highly Accessed Research article

The occupational risk of Helicobacter pylori infection among gastroenterologists and their assistants

Claudia Peters1*, Anja Schablon1, Melanie Harling1, Claudia Wohlert1, José Torres Costa2 and Albert Nienhaus1

Author Affiliations

1 University Medical Center Hamburg-Eppendorf, Institute for Health Service Research in Dermatology and Nursing, Hamburg, Germany

2 Occupational Health Division, Allergy and Clinical Immunology Division, Faculty of Medicine, Porto University, Porto, Portugal

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BMC Infectious Diseases 2011, 11:154  doi:10.1186/1471-2334-11-154

Published: 31 May 2011

Abstract

Background

Helicobacter pylori is a widely spread bacterium that mainly inhabits the gastric mucosa and can lead to serious illnesses such as peptic ulcer disease, gastric carcinoma and gastric MALT lymphoma. The oral-oral route seems to be the main transmission route. The fact that endoscopes are contaminated after being used to perform a gastroscopy leads one to question whether gastroenterologists and endoscopy nurses and assistants run a higher risk of infection.

Methods

A systematic search for literature was conducted in the MEDLINE and EMBASE databases and further publications were found in reference lists of relevant articles. Epidemiological studies on the occupational exposure of endoscopy personnel were collected and their quality was assessed. Pooled effect estimates were identified in a meta-analysis.

Results

Of the 24 studies included in the analysis, 15 were considered to be methodologically good. Of these 15 studies, eight single studies showed a statistically significant increased risk of infection for gastroenterologists, and five for their assistants. Meta-analysis across all methodologically good studies found a statistically significant risk of 1.6 (95%CI 1.3-2.0) for doctors. The pooled effect estimates also indicated a statistically significant risk of Helicobacter pylori infection (RR 1.4; 95%CI 1.1-1.8) for assistants too.

When studies are stratified by medical and non-medical control groups, statistically significant risks can only be recognised in the comparison with non-medical controls.

Conclusions

In summary, our results demonstrated an increased risk of Helicobacter pylori infection among gastroenterological personnel. However, the choice of control group is important for making a valid assessment of occupational exposure risks.