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Open Access Highly Accessed Research article

Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis

Evy Gillet12, Joris FA Meys3, Hans Verstraelen4, Carolyne Bosire1, Philippe De Sutter2, Marleen Temmerman1 and Davy Vanden Broeck1*

Author Affiliations

1 International Centre for Reproductive Health (ICRH), Ghent University, Ghent, Belgium

2 Department of Gynaecology, Vrije Universiteit Brussel, Brussels, Belgium

3 Department of Applied mathematics, biometrics and process control, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium

4 Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium

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BMC Infectious Diseases 2011, 11:10  doi:10.1186/1471-2334-11-10

Published: 11 January 2011

Abstract

Background

Bacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection.

Methods

Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model.

Results

Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84).

Conclusion

This meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.