Research article
Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan
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* Corresponding author: Syed H Ali syed.ali@aku.edu
1 Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
2 Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Hawaii, USA
3 Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
4 Department of Microbiology, University of Karachi, Pakistan
BMC Infectious Diseases 2010, 10:7 doi:10.1186/1471-2334-10-7
Published: 12 January 2010Additional files
Additional file 1:
Homology among the IDU sequences. 26 HIV gag sequences from IDUs were aligned using Clustal X and then the idenetity matrix was constructed using the BioEdit software. The matrix shows strong homology (98% or higher identity) among the 26 sequences compared.
Format: PSD Size: 358KB Download file
Additional file 2:
Clustering of HIV nef IDU sequences. Representative phylogenetic tree, constructed by the CLUSTAL W program, using the neighbor-joining method. The tree is based on the entire nef gene sequence of 15 HIV-1 strains from IDU in Karachi, Pakistan (enclosed in the red box) and 66 HIV-1 sequences belonging to various HIV-1 subtypes deposited in the Los Alamos database.
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