Before (y-axis) and after (x-axis) HAART initiation CD4+ T-cell (CD4+) counts of type-specific new HPV events. CD4+ counts for all new infections (I) and clearance (C) for a) all high-risk HPV types (I:81 in 49 female adolescents, C:39 in 26 participants); b) possible carcinogenic types (I:51 in 36 participants, C:12 in 11 infections); c) HPV 16 (I:6 in 6 participants, C:9 in 9 participants); and d) HPV 18 (11 in 11 participants and 5 in 5 participants). For new infections, the before HAART initiation CD4+ count was the mean from all pre-HAART HPV-negative visits, and the after HAART initiation CD4+ count was the average value of the last post-HAART HPV-negative visit and the first HPV-positive visit. For clearance, the before HAART initiation CD4+ count was the mean from all pre-HAART HPV-positive visits, and the after HAART initiation CD4+ count was the average value of the last post-HAART HPV-positive visit and the first HPV-negative visit (at least two consecutive HPV-negative visits).
Shrestha et al. BMC Infectious Diseases 2010 10:295 doi:10.1186/1471-2334-10-295