Table 5

Summary of Widal performances in earlier studies

Authors

Date

Study Country

Sample Size

Age classes included

Prevalence of S. typhi in participants

Sensitivity

Specificity

PPV

NPV

Cut Off Titer

Control Group(s)

Gold Standard


Choo et al.

1993

Malaysia

2382

Children

6.1%

89%

89%

< 50%

99.2%

O or H ≥1:40

Non-typhoid febrile children admitted to hospital

Blood Culture


Parry et al.

1999

Vietnam

2000

Children & Adults

30.8%

O: 49%

H: 67%;

O or H ≥1:100:88%

O: 97%

H: 96%;

O or H ≥1:100:87%

O: 88%

H: 88%;

O or H ≥1:100:74%

O: 82%

H: 87%;

O or H ≥1:100:94%

O:≥1:200

H: ≥1:100;

O or H ≥1:100

Lab confirmed malaria, dengue or bacteremia

Blood Culture


Wilke et al.

2002

Turkey

410

≥18 y

13.2%

52%

Post 7-10 d: 90%

88%

Post 7-10 d: 90%

76%

Post 7-10 d: 88%

71%

Post 7-10 d: 93%

O: ≥1:200

H: ≥1:200

Healthy controls, nontyphoidal febrile patients, blood culture negative febrile cases

Blood Culture, Stool Culture


Olsen et al.

2004

Vietnam

80

≥3y

73.8%

64% (field)

61% (lab)

76% (field)

100% (lab)

88% (field)

100% (lab)

43% (field)

48% (lab)

O or H ≥1:100

Lab confirmed bacteremia, AFB, dengue, malaria, pos. stool culture, pos. urine culture

Blood Culture


Ley et al.

This study

Tanzania

1680

2 m. - 14y

1%

75%

98%

26%

100%

H: ≥1:80

Non-typhoid febrile children admitted to hospital

Blood Culture


Ley et al. BMC Infectious Diseases 2010 10:180   doi:10.1186/1471-2334-10-180

Open Data