Table 3

Post-vaccination geometric mean titres (GMT) and ratios of GMT (adjuvanted vaccine/intradermal vaccine) for the three virus strains on day 21 in the per protocol set assessed by the haemagglutinin inhibition (HI) and single radial haemolysis (SRH) methods

HI method (1/dil)

SRH method (mm2)


Intradermal vaccine

(N = 390)

Adjuvanted vaccine

(N = 385)

Intradermal vaccine

(N = 389)

Adjuvanted vaccine

(N = 382)

Virus strain

Pre or Post vaccination

GMT

[95% CI]

Ratios of GMT

[95% CI]

GMT [95% CI]

Ratios of GMT

[95% CI]


A/H1N1

Pre-

13.3 [12.1;14.6]

13.5 [12.3;14.9]

--

7.7 [6.9;8.6]

8.0 [7.2;8.9]

--

Post-

108.3 [95.4;123.0]

122.1 [109.1;136.7]

1.13 [0.95;1.34]*

46.4 [41.6;51.8]

53.9 [49.0;59.3]

1.16 [1.00;1.34]*

A/H3N2

Pre-

60.3 [52.2;69.7]

69.4 [59.5;81.0]

--

11.0 [9.8;12.5]

12.7 [11.2;14.3]

--

Post-

259.9 [233.5;289.3]

341.4 [306.7;380.1]

1.31 [1.13;1.53]

39.3 [35.6;43.3]

46.2 [42.1;50.7]

1.18 [1.03;1.34]*

B

Pre-

15.0 [13.7;16.4]

16.5 [15.1;18.1]

--

29.2 [25.6;33.2]

28.0 [24.5;32.1)

--

Post-

36.9 [33.6;40.5]

39.9 [36.4;43.8]

1.08 [0.95;1.23]*

66.5 [60.8;72.8]

68.9 [62.9;75.3]

1.03 [0.91;1.17]*


*Non-inferiority of the intradermal vaccine was demonstrated if the upper bound of the 95% CI for the ratios of GMT was < 1.5.

Van Damme et al. BMC Infectious Diseases 2010 10:134   doi:10.1186/1471-2334-10-134

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