Email updates

Keep up to date with the latest news and content from BMC Infectious Diseases and BioMed Central.

Open Access Highly Accessed Open Badges Research article

Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis

Christian Østergaard12*, Stephen L Leib3, Ian Rowland45 and Christian T Brandt26

Author Affiliations

1 Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev, Denmark

2 National Center for Antimicrobials and Infection Control, Statens Serum Institute, Copenhagen, Denmark

3 Institute for Infectious Diseases, University of Bern, Bern, Switzerland

4 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

5 Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA

6 Copenhagen HIV Programme, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

For all author emails, please log on.

BMC Infectious Diseases 2010, 10:1  doi:10.1186/1471-2334-10-1

Published: 3 January 2010



Bacteremia and systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis. Their individual contributions to the development of brain damage, however, still remain to be defined.


Using an adult rat pneumococcal meningitis model, the impact of bacteremia accompanying meningitis on the development of hippocampal injury was studied. The study comprised of the three groups: I. Meningitis (n = 11), II. meningitis with attenuated bacteremia resulting from iv injection of serotype-specific pneumococcal antibodies (n = 14), and III. uninfected controls (n = 6).


Pneumococcal meningitis resulted in a significantly higher apoptosis score 0.22 (0.18-0.35) compared to uninfected controls (0.02 (0.00-0.02), Mann Whitney test, P = 0.0003). Also, meningitis with an attenuation of bacteremia by antibody treatment resulted in significantly reduced apoptosis (0.08 (0.02-0.20), P = 0.01) as compared to meningitis.


Our results demonstrate that bacteremia accompanying meningitis plays an important role in the development of hippocampal injury in pneumococcal meningitis.