Research article

Bacteremia in hospitalized patients with human immunodeficiency virus: A prospective, cohort study

Bekele Afessa^1,2,3 , Ian Morales^2,3 and Bethany Weaver^2,4

¹  From the Division of Pulmonary and Critical Care, University of Florida Health Science Center, Jacksonville, Florida, USA

²  Department of Internal Medicine, University of Florida Health Science Center, Jacksonville, Florida, USA

³  Current affiliations Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN USA

⁴  Current affiliations Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Box 35931, Seattle, WA 98104, USA

author email corresponding author email

BMC Infectious Diseases 2001, 1:13doi:10.1186/1471-2334-1-13

Published:	7 September 2001

Abstract

Background

Bacterial infections complicate the course of patients with human immunodeficiency virus infection. The purpose of this study was to describe the bacterial pathogens causing blood stream infection, identify the risk factors for the development of blood stream infection and determine the impact of blood stream infection on the outcome of patients infected with human immunodeficiency virus.

Methods

The incidence, etiology, risk factors and outcome of bacterial blood stream infection were prospectively determined in 1,225 consecutive hospitalizations of adults with human immunodeficiency virus infection.

Results

Blood stream infection occurred in 88 hospitalizations (7%); 73 of 89 infections (82%) were community acquired. The most commonly isolated gram-positive organism was Streptococcus pneumoniae (21); gram-negative, Escherichia coli (14). Blood stream infection was detected in 8% of African Americans and 22% of Hispanics compared with 2% of whites (P = 0.0013). Patients with blood stream infection had higher white blood cell counts (median, 6.5 vs. 4.9 × 10⁹/L; P = 0.0002) and mortality (18% vs. 4%; P < 0.0001) than patients without infection.

Conclusions

In patients with human immunodeficiency virus, blood stream infection is associated with an increased mortality rate. Recognition of the incidence, etiology, and risk factors of blood stream infection in patients with human immunodeficiency virus infection could lead to measures that reduce the increased mortality.