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Open Access Research article

Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study

Misaki Wayengera

Author Affiliations

Unit of Genetics, Genomics & Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P o Box 7072, Kampala, Uganda

BMC Blood Disorders 2012, 12:5  doi:10.1186/1471-2326-12-5

Published: 14 May 2012

Additional files

Additional file 1:

A detailed list of the 1,606 nucleotide bases within the Hemoglobin, beta gene. This file offers FASTA-format listing of the 1,606 nucleotide bases within the Hemoglobin, beta gene (gene identity |3043|).

Format: DOC Size: 30KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

A detailed list of the57ZFAs specific to the Hemoglobin, beta gene-sequences. This file lists the 57 ZFAs that specifically bind sequences within the Hemoglobin, beta gene

Format: DOC Size: 1.5MB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

A detailed list of thefourZFNs specific to the Hemoglobin, beta gene-sequences. This file lists the four ZFNs that specifically bind and cleave sequences within the Hemoglobin, beta gene

Format: DOC Size: 135KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 4:

A detailed list of the 8,954 bp located to the 5′ end of theβAchain gene. This file offers FASTA-format listing of the 8,954 bp located to the 5′ end of the βA chain gene. (NCBI reference sequence 5190000 to 5198951 is |NT_009237.18|)

Format: DOC Size: 53KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 5:

A detailed list of thefiveZFNs specific to the 8,954 bp located to the 5′ end of theβAchain gene. This file lists the fives ZFNs that specifically bind and cleave sequences within the 8,954 bp located to the 5′ end of the βA chain gene.

Format: DOC Size: 180KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data