Table 1

Clinical characteristics of SCA patients by HbF level
Characteristic Patients with High HbF levels (≥10%) N = 80(%) Patients with low HbF levels (<10%) N = 136 (%) OR (95% CI) p value
Demographic features
Gender
Female 48(60%) 67(49.3%) 1.54 (0.88-2.71) 0.128
Male 32(40%) 69(50.7%)
Age
<5 years 28 (35%) 20 (14.7%) 3.12 (1.58 -6.17) 0.0005
≥ 5 years 52 (65%) 116 (85.3%)
HISTORY
Reason for clinic visit
Sick visit 63(77%) 100 (73.5%) 1.33 (0.69-2.57) 0.390
Routine visit 17 (23%) 36 (26.5%)
Duration of follow up in SCC
< 5 years 54 (67.5%) 52 (38.2%) 3.36 (1.83-6.16) <0.001
≥ 5 year 26 (32.5%) 84 (61.8%)
Transfusions since birth
<3 58 (72.5%) 83 (61%) 1.68 (0.91-3.08) 0.080
≥ 3 22(27.5%) 53 (39%)
Hospitalisations since birth
≤2 48 (60%) 61(55%) 1.82 (1.03- 3.21) 0.036
>2 32 (40%) 75 (45%)
SIGNS
Jaundice
present 53(66.3%) 85 (62.5%) 1.18 (0.66-2.11) 0.580
absent 27 (33.7%) 51 (37.5%)
Palpable spleen
Yes 24 (30%) 28 (20.6%) 1.65 (0.87-3.13) 0.119
No 56 (60%) 108 (79.4%)
Hepatomegaly
Present 40 (50%) 60 (44.1%) 1.27 (0.73-2.21) 0.404
absent 40 (50%) 76 (55.9%)
Haematological parameters
WBC count
<15.0 35 (43.8%) 65 (47.8%) 1.18 (0.67-2.05) 0.566
≥ 15.0 45 (56.2%) 71 (52.2%)
RBC count
<3.0 48 (60%) 80 (58.8%) 1.05 (0.60-1.85) 0.865
≥ 3.0 32 (40%) 56 (41.2%)
Hb level
≥7 g/dl 60 (75%) 98 (72.1%) 1.16 (0.62-2.19) 0.638
<7 g/dl 20 (25%) 38 (27.9%)
PLT level
<400 40 (50%) 66 (48.5% 1.06 (0.61-1.85) 0.835
≥400 40 (50%) 70 (51.5%)

Mpalampa et al.

Mpalampa et al. BMC Blood Disorders 2012 12:11   doi:10.1186/1471-2326-12-11

Open Data