A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the

doi:10.1186/1471-2318-9-19

BMC Geriatrics

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Albani D
Batelli S
Polito L
Vittori A
Pesaresi M
Gajo GB
De Angeli S
Zanardo A
Gallucci M
Forloni G

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Albani D
Batelli S
Polito L
Vittori A
Pesaresi M
Gajo GB
De Angeli S
Zanardo A
Gallucci M
Forloni G
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Research article

A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study

Diego Albani¹ , Sara Batelli¹ , Letizia Polito¹ , Angelica Vittori¹ , Marzia Pesaresi¹ , Giovanni Battista Gajo²^,3 , Sergio De Angeli²^,3 , Andrea Zanardo²^,4 , Maurizio Gallucci²^,5 and Gianluigi Forloni¹

¹Department of Neuroscience, "Mario Negri" Institute for Pharmacological Research, via La Masa 19, I-20156 Milan, Italy

²ARGEI, Interdisciplinary Geriatric Research Association, Trento Trieste Avenue 19, I-31100 Treviso, Italy

³Trasfusional Center Treviso General Hospital, Piazza Ospedale 1, I-31100 Treviso, Italy

⁴Clinical Chemistry Laboratory Treviso General Hospital, Piazza Ospedale, 1 I-31100 Treviso Italy

⁵Treviso General Hospital, Piazza Ospedale, 1 I-31100 Treviso Italy

author email corresponding author email

BMC Geriatrics 2009, 9:19doi:10.1186/1471-2318-9-19


Published:	21 May 2009

Abstract

Background

An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R).

Methods

In an elderly population from North-eastern Italy (n = 668 subjects, age range 70–106 years) we investigated the IGF-1R polymorphism G3174A (rs2229765) and the plasma concentration of free IGF-1. Frequency distributions were compared using χ²-test "Goodness of Fit" test, and means were compared by one-way analysis of variance (ANOVA); multiple regression analysis was performed using JMP7 for SAS software (SAS Institute, USA). The limit of significance for genetic and biochemical comparison was set at α = 0.05.

Results

Males showed an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age (85+ group). In the male 85+ group, A/A homozygous subjects had the lowest plasma IGF-1 level. We found no clear correlation between rs2229765 genotype and IGF-1 in the females.

Conclusion

These findings confirm the importance of the rs2229765 minor allele as a genetic predisposing factor for longevity in Italy where a sex-specific pattern for IGF-1 attenuation with ageing was found.