Table 4

Discriminant validity of Mindstreams computerized tests: summary statistics and group differences (Mann-Whitney U).

Cognitive Domain

Mindstreams Test (outcome parameter)

Healthy Elderly N = 39

MCI N = 30

Mild AD N = 29

MCI / Healthy Elderly p-value

MCI / Mild AD p-value


MEMORY

Verbal Memory (accuracy, first repetition trial)

71.35 (18.88)

48.21 (22.94)

24.00 (20.41)

0.000

0.000

Verbal Memory (accuracy, second repetition trial)

87.37 (13.09)

60.71 (25.08)

23.60 (23.96)

0.000

0.000

Verbal Memory (accuracy, third repetition trial)

94.47 (7.60)

71.43 (29.9)

20.80 (22.16)

0.000

0.000

Verbal Memory Accuracy (accuracy, final repetition trial)

97.37 (5.54)

73.21 (29.07)

22.00 (23.8)

0.000

0.000

Verbal Memory (accuracy, all repetition trials)

88.08 (8.51)

63.68 (24.13)

22.76 (21.72)

0.000

0.000

Verbal Memory (accuracy, delayed recognition)

87.30 (12.17)

62.50 (30.26)

18.40 (19.30)

0.000

0.000

Non-Verbal Memory (accuracy, first repetition trial)

49.92 (21.25)

38.71 (15.61)

27.96 (16.35)

0.027

0.017

Non-Verbal Memory (accuracy, second repetition trial)

63.11 (20.63)

46.68 (25.91)

30.13 (13.95)

0.006

0.014

Non-Verbal Memory (accuracy, third repetition trial)

74.89 (23.65)

55.18 (27.44)

30.74 (17.98)

0.003

0.002

Non-Verbal Memory Accuracy (accuracy, final repetition trial)

82.84 (18.19)

55.64 (28.36)

28.92 (15.33)

0.000

0.000

Non-Verbal Memory (accuracy, all repetition trials)

67.79 (17.17)

49.21 (20.36)

28.96 (11.24)

0.000

0.000

Non-Verbal Memory (accuracy, delayed recognition)

74.92 (21.92)

55.14 (25.00)

37.68 (17.65)

0.002

0.012


EXECUTIVE FUNCTION

Go-NoGo (accuracy)

94.28 (6.59)

84.89 (18.93)

81.90 (14.19)

0.001

0.238

Go-NoGo (performance index)

20.55 (2.63)

16.47 (3.75)

13.68 (4.77)

0.000

0.036

Problem Solving (accuracy)

73.45 (15.27)

61.36 (13.09)

55.00 (15.62)

0.000

0.161

Stroop Interference (performance index)

11.70 (6.40)

7.16 (5.38)

---

0.023

---

Catch Game (accuracy)

59.67 (14.91)

46.24 (19.80)

---

0.016

---


VISUAL SPATIAL

Visual Spatial Imagery (accuracy)

60.16 (15.61)

44.37 (15.53)

35.56 (15.43)

0.000

0.015


VERBAL

Verbal Function (accuracy, naming)

92.33 (8.79)

83.22 (14.05)

66.96 (18.37)

0.004

0.002

Verbal Function (accuracy, rhyming)

80.38 (16.97)

52.21 (29.36)

37.79 (22.79)

0.000

0.02


ATTENTION

Go-NoGo (RT)

464.39 (56.66)

556.04 (102.82)

666.38 (243.81)

0.000

0.244

Go-NoGo (standard deviation of RT)

119.17 (46.40)

171.96 (89.02)

242.81 (160.75)

0.006

0.149

Choice Reaction Time (performance index)

15.84 (3.84)

15.52 (5.51)

9.34 (4.41)

0.894

0.004


INFORMATION PROCESSING

Staged Information Processing, Low Load (performance index)

15.21 (1.91)

14.52 (2.28)

---

0.345

---

Staged Information Processing, Medium Load (performance index)

8.83 (1.55)

7.04 (1.75)

---

0.001

---

Staged Information Processing, High Load (performance index)

5.55 (1.16)

4.71 (1.51)

---

0.037

---


MOTOR SKILLS

Finger Tapping (inter-tap interval)

221.10 (42.71)

242.83 (64.88)

279.00 (66.09)

0.215

0.055

Finger Tapping (standard deviation of inter-tap interval)

38.38 (28.82)

58.35 (49.46)

66.62 (78.09)

0.101

0.888

Catch Game (time to first move)

774.91 (158.10)

783.14 (169.16)

---

0.797

---


Summary statistics presented as mean (standard deviation). Accuracies are given as percent correct. Timed outcome parameters are given in milliseconds. '---' indicates insufficient data (<13 data points per group) due to failed practice sessions (see Methods). MCI = mild cognitive impairment AD = Alzheimer's disease RT = reaction time

Dwolatzky et al. BMC Geriatrics 2003 3:4   doi:10.1186/1471-2318-3-4

Open Data