Open Access Study protocol

The effect of testosterone and a nutritional supplement on hospital admissions in under-nourished, older people

Cynthia Piantadosi1, Renuka Visvanathan1*, Vasi Naganathan2, Peter Hunter3, Ian D Cameron4, Kylie Lange5, Jonathan Karnon6 and Ian M Chapman5

Author Affiliations

1 The Health Observatory, University of Adelaide, Department of Medicine, Adelaide SA 5005, Australia

2 University of Sydney, Concord Hospital, Concord NSW 2139, Australia

3 Alfred Health, Caulfield Hospital 260, Caulfield Vic 3162, Australia

4 Rehabilitation Studies Unit, University of Sydney, Ryde NSW 1680, Australia

5 University of Adelaide, Department of Medicine, Adelaide SA 5005, Australia

6 University of Adelaide, Department of Public Health, SA 5005, Australia

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BMC Geriatrics 2011, 11:66  doi:10.1186/1471-2318-11-66

Published: 24 October 2011

Abstract

Background

Weight loss and under-nutrition are relatively common in older people, and are associated with poor outcomes including increased rates of hospital admissions and death. In a pilot study of 49 undernourished older, community dwelling people we found that daily treatment for one year with a combination of testosterone tablets and a nutritional supplement produced a significant reduction in hospitalizations. We propose a larger, multicentre study to explore and hopefully confirm this exciting, potentially important finding (NHMRC project grant number 627178).

Methods/Design

One year randomized control trial where subjects are allocated to either oral testosterone undecanoate and high calorie oral nutritional supplement or placebo medication and low calorie oral nutritional supplementation. 200 older community-dwelling, undernourished people [Mini Nutritional Assessment score <24 and either: a) low body weight (body mass index, in kg/m2: <22) or b) recent weight loss (>7.5% over 3 months)]. Hospital admissions, quality-adjusted life years, functional status, nutritional health, muscle strength, body composition and other variables will be assessed.

Discussion

The pilot study showed that combined treatment with an oral testosterone and a supplement drink was well tolerated and safe, and reduced the number of people hospitalised and duration of hospital admissions in undernourished, community dwelling older people. This is an exciting finding, as it identifies a treatment which may be of substantial benefit to many older people in our community. We now propose to conduct a multi-centre study to test these findings in a substantially larger subject group, and to determine the cost effectiveness of this treatment.

Trial registration

Australian Clinical Trial Registry: ACTRN 12610000356066