Table 1

Mortality rates in cases of upper gastrointestinal bleed or perforation according to date of publication and size of study, for all cases and those taking NSAID

All Cases

Cases using NSAIDs

Number of

Number of

Analysis

Cases

Deaths

Mortality (%; 95% CI)

Cases

Deaths

Mortality (%; 95% CI)

Overall

61067

5001

8.2

(8.0 to 8.4)

5526

904

16.4

(15.4 to 17.3)

By date of publication

Before 1997 [1]

11361

1319

11.6

(11.0 to 12.2)

4046

595

14.7

(13.6 to 15.8)

Between 1997 and 2008

49706

3682

7.4

(7.2 to 7.6)

1480

309

20.9

(18.8 to 22.9)

By number of cases

≥ 2000

35058

2410

6.9

(6.6 to 7.1)

3443

576

16.7

15.5 to 18.0)

200–1999

23147

2345

10.1

(9.7 to 10.5)

1465

297

20.3

(18.2 to 22.3)

1–199

2862

246

8.6

(7.6 to 9.6)

618

31

5.0

(3.3 to 6.7)

Straube et al. BMC Gastroenterology 2009 9:41   doi:10.1186/1471-230X-9-41