Open Access Research article

Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan

Tomoyuki Akiyama1, Masahiko Inamori1*, Hiroshi Iida1, Hiroki Endo1, Kunihiro Hosono1, Kyoko Yoneda1, Koji Fujita1, Masato Yoneda1, Hirokazu Takahashi1, Ayumu Goto1, Yasunobu Abe1, Hiroyuki Kirikoshi1, Noritoshi Kobayashi1, Kensuke Kubota1, Satoru Saito1, Yasushi Rino2 and Atsushi Nakajima1

Author Affiliations

1 Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan

2 Surgery Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan

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BMC Gastroenterology 2009, 9:34  doi:10.1186/1471-230X-9-34

Published: 18 May 2009

Abstract

Background

We aimed to estimate whether the macroscopic extent of gastric mucosal atrophy is associated with a risk for esophageal squamous cell carcinoma using a case-control study in Japanese subjects, a population known to have a high prevalence of CagA-positive H. pylori infection.

Methods

Two hundred and fifty-three patients who were diagnosed as having esophageal squamous cell carcinoma, and 253 sex- and age-matched controls were enrolled in the present study. The macroscopic extent of gastric mucosal atrophy was evaluated based on the Kimura and Takemoto Classification. A conditional logistic regression model with adjustment for potential confounding factors was used to assess the associations.

Results

Body gastritis, defined endoscopically, was independently associated with an increased risk for esophageal squamous cell carcinoma.

Conclusion

Our findings suggest that macroscopic body gastritis may be a risk factor for esophageal squamous cell carcinoma in Japan. Further studies are needed to confirm these findings.