Table 2

Change in histopathologic scores (mean ± SD)*

Sham

BDL

BDL + vehicle

BDL + fenofibrate

Portal inflammation

0

3.2 ± 0.2^a

3.1 ± 0.7^a

2.0 ± 0.5^a,b,c

Interface hepatitis

0

1.8 ± 0.7^a

1.7 ± 0.9^a

1.3 ± 0.6^a,b,c

Confluent necrosis

0

2.2 ± 0.^a

2.1 ± 0.9^a

1.1 ± 0.2^a,b,c

Lobar necrosis

0

3.0 ± 0.9^a

2.9 ± 0.7^a

2.1 ± 0.8^a,b,c

Bile duct number/5 portal field

3.5 ± 1.3

18.9 ± 8.0^a

17.5 ± 7.1^a

23.2 ± 11.1^a,b,c

*Comparisons between groups were done by using Kruskal-Wallis test. Paired comparisons are done by using Mann-Whitney U test.

^aP < 0.01 versus sham group (Mann-Whitney U)

^bP < 0.01 as compared to BDL group (Mann-Whitney U)

^cP < 0.01 as compared to BDL + vehicle group (Mann-Whitney U)

Cindoruk et al. BMC Gastroenterology 2007 7:44   doi:10.1186/1471-230X-7-44