Normal activation of cell-associated hepatocyte growth factor in uPAR° livers during liver repair. Western analysis of hepatocyte growth factor (HGF) partially purified from the soluble fraction of liver extracts using an antibody that recognizes the single chain and heavy chain (to demonstrate activation) of HGF shows similar levels of activation in WT and uPAR° livers at baseline (day 0) or at 2 days after CCl4 administration. scHGF = single chain HGF; aHGF = activated HGF, rHGF = recombinant HGF.
Shanmukhappa et al. BMC Gastroenterology 2006 6:40 doi:10.1186/1471-230X-6-40