Transient decrease in proliferation of hepatocytes in mice lacking uPAR. Quantification of BrdU-labeled hepatocytes shows a rise in BrdU uptake in all experimental groups 2 days after CCl4, with a decrease of ~33% in uPAR° livers. The percent of BrdU-labeled hepatocytes return to near baseline levels in all groups. WT = wild type. (*ANOVA P < 0.004; @t-test P < 0.004; N = 3–8 at each time point).
Shanmukhappa et al. BMC Gastroenterology 2006 6:40 doi:10.1186/1471-230X-6-40