IL-10 gene transfected SVEC is resistant to TNF-α induced MAdCAM-1 expression. TNF-α (1 ng/ml, 24 h) significantly increased expression of MAdCAM-1 and this was significantly blocked by IL-10 gene transfection. Alone, IL-10 gene transfer had no effect on MAdCAM-1 expression (n = 5). (* p < 0.05 from TNF-α, # p < 0.05 from control). One-way ANOVA with Fisher's PLSD test.
Sasaki et al. BMC Gastroenterology 2003 3:3 doi:10.1186/1471-230X-3-3