Table 2

Logistic regression analysis on moderate to severe stage of fibrosis
Stage > =2 (n = 15) n (%) or Mean (SD) Stage < 2 (n = 30) n (%) or Mean (SD) Univariable logistic regression Multivariable logistic regression***
Variable OR 95% CI p-value p-value
Age 46.87 (13.93) 40.17 (10.72) 1.05 0.993; 1.110 0.089
Gender, N (%) Male 11 (42.31) 15 (57.69) 2.75 0.713; 10.605 0.1418 0.0641
Female* 4 (21.05) 15 (78.95)
Race, N (%) Caucasian* 1 (16.67) 5 (83.33) 0.2845
AA 9 (50.00) 9(50.00) 5 0.483; 51.769
Asian 4 (22.22) 14 (77.78) 1.429 0.127; 16.025
Other 1 (33.33) 2 (66.67) 2.5 0.1; 62.602
Diagnosis HBV 7 (21.21) 26 (78.79) 0.135 0.031; 0.581 0.0072** 0.0156**
HIV/HBV* 8 (66.67) 4 (33.33)
Inflammation Grade > 1 12 (57.14) 9 (42.86) 9.333 2.110; 41.278 0.0032** 0.0066**
Grade < =1* 3 (12.50) 21 (87.50)
FibroSURE 0.462 (0.297) 0.212 (0.167) 3.015§ 1.426; 6.374 0.0039** 0.0158**
log10 ALT (U/L) 1.81 (0.25) 1.52 (0.28) 3.314§ 1.393; 7.883 0.0067**
log10 AST (U/L) 1.70 (0.21) 1.51 (0.25) 2.455§ 1.065; 5.658 0.0350**
log10 HBV DNA (IU/ml) 5.24 (2.98) 4.60 (2.39) 1.304§ 0.674; 2.520 0.4303

*Reference group for the reported odds ratios.

**p-value < 0.05.

***Based on the best selected model.

§OR of 1 SD increase.

Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, HBV hepatitis B virus, SD standard deviation, OR odds ratio, CI confidence interval, AA African-American, HIV human immunodefiency virus.

Zeremski et al.

Zeremski et al. BMC Gastroenterology 2014 14:118   doi:10.1186/1471-230X-14-118

Open Data