Table 2

Characteristics of 77 Crohn patients with pediatric-onset according to the Montreal classification regarding BMD adjusted for age
Pediatric-onset CD patients Low BMD Normal BMD p-value
Z-score<−1 Z-score ≥−1
n=77 n=46 n=31
% 60% 40%
NOD2 variant n (%) 24 (52%) 10 (32%) p=0.10
One variant allele 17 5 p=0.061
Two variant alleles 7 5 p=0.75
Homozygous variant alleles 7 0 p=0.037*
Gender: female/male in % 45/55 48/52 p=0.89
Age: y
mean/SD 25/12.8 24/13.9 p=0.62
median/interquartile range 21/17-30 19/15-29 p=0.29
average disease duration/SD 12.2/11.6 11.6/10.8 p=0.84
Age at diagnosis: y
mean/SD 13/3.6 12/5.1 p=0.33
median/interquartile range 14/11-16 13/10-17 p=0.69
Localization: n (%)
L1 ileal 8 (17%) 9 (29%) p=0.27
L2 colonic 8 (17%) 6 (19%) p=1.0
L3 ileocolonic 30 (65%) 16 (52%) p=0.25
L4 isolated upper disease 0 (0%) 0 (0%) p=1.0
Upper GI involvement 15 (33%) 13 (42%) p=0.47
Behaviour: n (%)
B1 non-stricturing/penetrating 27 (59%) 20 (65%) p=0.64
B2 stricturing 11 (23%) 6 (19%) p=0.78
B3 penetrating intern 6 (13%) 3 (10%) p=0.73
B3p penetrating perianal 9 (19%) 3 (10%) p=0.34
Underweight at diagnosis 14/27 (52%) 5/22 (32%) p=0.0453*
Underweight in 1y follow-up 14 (30%) 2 (6%) p=0.0113*
Short stature 5 (11%) 1 (3%) p=0.39
Treatment: n (%)
Steroid dependent/refractory 23 (50%) 9 (29%) p=0.10
Azathioprine / MTX 35 (76%) 15 (48%) p=0.016*
Anti-TNFα-antibody 20 (44%) 7 (26%) p=0.09

* indicates p value ≤ 0.05 considered to be significant.

Posovszky et al.

Posovszky et al. BMC Gastroenterology 2013 13:77   doi:10.1186/1471-230X-13-77

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