Table 1

Characteristics of 202 patients with pediatric- and adult-onset Crohn’s disease according to the Montreal classification[22]regarding NOD2 genotype at latest follow-up
Patients Pediatric-onset CD (≤18 y) Adult-onset CD (>18 y)
n=202 n=85 n=117
NOD2 genotype Main variants Wild-type p-value Main variants Wild-type p-value
Number: n (%) 37 (44%) 48 (56%) 47 (40%) 70 (60%) 0.67
1 variant allele 23 (27%) 37 (32%)
2 variant alleles 14 (16%) 10 (9%) 0.12
homozygous variant alleles 7 (8%) 3 (3%) 0.099
Gender: female/male (%) 57/43 38/62 0.08 51/49 59/41 0.39
Age: year
mean/SD 26/13.0 22.7/12.6 0.26 47.3/14.3 46.5/13.4 0.67
median/interquartile range 22/17-35 20/15-26 0.18 46/36-62 45/36-54 0.78
average disease duration/SD 12.8/11.2 11.3/10.5 0.63 16.2/11.3 16.5/10.3 0.89
Age at diagnosis: year
mean/SD 13.9/3.3 12.1/4.9 0.07 31.5/10.0 30.5/10.6 0.49
median/interquartile range 15.0/12-17 13.0/9-17 0.18 27/23-33 29/24-38 0.32
Localization: n (%)
L1 ileal 9 (24%) 12 (25%) 1.0 18 (38%) 14 (21%) 0.058
L2 colonic 3 (8%) 13 (27%) 0.048* 4 (8%) 11 (16%) 0.27
L3 ileocolonic 26 (68%) 23 (48%) 0.048* 25 (53%) 41 (61%) 0.35
L4 isolated upper disease 0 (0%) 0 (0%) 1.0 0 (0%) 1 (1%) 1.0
Upper GI involvement 12 (32%) 16 (33%) 1.0 1 (2%) 7 (10%) 0.14
Behaviour: n (%)
B1 non-stricturing/penetrating 16 (43%) 33 (69%) 0.026* 16 (35%) 28 (41%) 0.53
B2 stricturing 15 (41%) 6 (13%) 0.005* 22 (48%) 20 (29%) 0.051
B3 penetrating intern 6 (16%) 3 (6%) 0.16 12 (26%) 11 (16%) 0.23
B3p penetrating perianal 7 (19%) 7 (15%) 0.76 8 (17%) 19 (28%) 0.27

* indicates p value ≤ 0.05 considered to be significant.

Posovszky et al.

Posovszky et al. BMC Gastroenterology 2013 13:77   doi:10.1186/1471-230X-13-77

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