Table 2

Clinical and molecular characteristics of colon cancer patients according to MMR and CIMP1
Molecular classifiers
MMR system frequency N% CIMP status frequency N%
Clinical and pathological parameters pMMR dMMR p CIMP-0 CIMP-L CIMP+ p
102 (85) 18 (15) 62 (52) 36 (30) 22 (18)
Sex Male 50 (59) 7 (39) 0.4 24 (39) 24 (67) 9 (41) 0.02
Female 52 (41) 11(61) 38 (61) 12 (33) 13 (59)
Tumour location Proximal 34 (33) 12 (67) <0.01 25 (40) 9 (25) 12 (54) 0.07
Distal 68 (67) 6 (33) 37 (60) 27 (75) 10 (46)
Tumour grade G1 13 (13) 3 (17) <0.01 8 (13) 6 (17) 2 (9) 0.04
G2 88 (86) 12 (67) 54 (87) 29 (81) 17 (77)
G3 1 (1) 3 (17) 0 (0) 1 (2) 3 (14)
Tumour inflammatory response No 51 (50) 4 (22) 0.03 26 (42) 20 (55) 9 (41) 0.4
Yes 51 (50) 14 (78) 36 (58) 16 (45) 13 (59)
Molecular parameters TS by mRNA High 44 (43) 13 (72) 0.02 22 (35) 19 (53) 16 (73) <0.01
Low 58 (57) 5 (28) 40 (65) 17 (47) 6 (27)
TS by IHC High 52 (51) 6 (33) 0.2 30 (48) 16 (44) 12 (55) 0.2
Low 50 (49) 12 (67) 32 (52) 20 (56) 10 (45)
TP53 Positive 44 (43) 2 (11) <0.01 27 (44) 9 (25) 10 (45) 0.1
35 (56) 27 (75) 12 (55)
Negative 58 (57) 16 (89)
CTNNB1 activation grades 1 34 (33) 11 (66) 0.02 19 (31) 19 (53) 7 (32) 0.08
2 54 (53) 3 (17) 33 (54) 15 (42) 9 (41)
3 14 (14) 3 (17) 9 (15) 2 (5) 6 (27)
BRAF c.1799 T>A Wild 91 (89) 13 (72) 0.05 54 (87) 32 (89) 18 (82) 0.7
Mutated 11 (11) 5 (28) 8 (13) 4 (11) 4 (18)

1Significant or borderline p values are bolded.

Donada et al.

Donada et al. BMC Gastroenterology 2013 13:36   doi:10.1186/1471-230X-13-36

Open Data