Pro-inflammatory gene expression is enhanced in GC-C−/− livers at 4 and 10 days post-infection. Real time RT-PCR was used to assess differences in liver gene expression from naive and infected mice at days 4 and 10 p.i. At day 4, levels of CXCL1, CXCL9, and LBP were increased in liver from GC-C−/− mice. Consistent with the obvious liver damage seen in the GC-C−/− mice at day 10, levels of IL-22, CXCL1, and CXCL9 were significantly elevated. All values are relative to the level in uninfected GC-C+/+ liver. Line represents median value. (**P ≤ 0.005, *P ≤ 0.05, n = 4-10 mice per group; D4, day 4 p.i.; D10, day 10 p.i.).
Mann et al. BMC Gastroenterology 2013 13:135 doi:10.1186/1471-230X-13-135