Additional file 4.
Figure S4.Deletion of Foxp3+Treg activates CD11b+cells to produce cytokines. (A-B) TNF and IL-1β production 10 days of Foxp3+ Treg deletion. CD11b+ cells were extracted from the spleen.Cytokine concentrations were determined in culture supernatants by ELISA. Data shown are the mean values ± SD from five mice per group analyzed duplicate. (C) Data shown are the tabular representation of the mean values ± SD of the concentration of the distinct secreted cytokines derived from five mice per group each analyzed in duplicate. (D) Comparison of the TNF and IL-1β production of CD11b+ cells isolated from Foxp3-GFP-DTR mice treated with DTx versus the two different control groups. Data shown are the corresponding p values analyzed by a two-tailed unpaired student’s t-test with a 95% confidence interval.
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Boehm et al. BMC Gastroenterology 2012 12:97 doi:10.1186/1471-230X-12-97