Representative analysis of liver tissue sections. Portal and periportal cellular inflammation: lymphocytes, monocytes/macrophages and plasma cells infiltrate the portal tracts and invade the surrounding parenchyma, resulting in the characteristic picture of interface hepatitis. (A) Enlarged portal tracts fields with fibrosis and marked bile ductular proliferation, severe inflammatory biliary tract damage; liver cells showing moderate microvescicular steatosis (H&E, 20X); (B) high-power view of an expanded portal tract field with moderate mixed inflammatory infiltrate and some features of flogistic bile duct damage (H&E, 40X). (C and D) Immunohistology for biliary type cytokeratin 7 shows marked ductular proliferation in portal tracts fields and biliary metaplasia (abnormal positivity to cytokeratin 7) of peri-portal hepatocytes (40 X).
Invernizzi et al. BMC Gastroenterology 2012 12:92 doi:10.1186/1471-230X-12-92