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Open Access Technical advance

Back-to-Back Comparison of Auto-Fluorescence Imaging (AFI) Versus High Resolution White Light Colonoscopy for Adenoma Detection

Kentaro Moriichi1, Mikihiro Fujiya1*, Ryu Sato23, Jiro Watari34, Yoshiki Nomura1, Toshie Nata1, Nobuhiro Ueno1, Shigeaki Maeda3, Shin Kashima13, Kentaro Itabashi1, Chisato Ishikawa1, Yuhei Inaba1, Takahiro Ito1, Kotaro Okamoto1, Hiroki Tanabe1, Yusuke Mizukami1, Yusuke Saitoh5 and Yutaka Kohgo1

Author Affiliations

1 Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan

2 Internal Medicine, Kotoni Royal Hospital, 2-Nishi1-1-1, Hachiken, Nishi-ku, Sapporo, Hokkaido, 063-0842, Japan

3 Internal Medicine, Kushiro Medical Association Hospital, 4-30 Nusamai-cho, Kushiro, Hokkaido, 085-0836, Japan

4 Division of Upper Gastroenteroelogy, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

5 Digestive Disease Center, Asahikawa City Hospital, 1-1-65 Kinsei-cho, Asahikawa, Hokkaido, 070-8610, Japan

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BMC Gastroenterology 2012, 12:75  doi:10.1186/1471-230X-12-75

Published: 22 June 2012

Abstract

Background

Some patients under close colonoscopic surveillance still develop colorectal cancer, thus suggesting the overlook of colorectal adenoma by endoscopists. AFI detects colorectal adenoma as a clear magenta, therefore the efficacy of AFI is expected to improve the detection ability of colorectal adenoma. The aim of this study is to determine the efficacy of AFI in detecting colorectal adenoma.

Methods

This study enrolled 88 patients who underwent colonoscopy at Asahikawa Medical University and Kushiro Medical Association Hospital. A randomly selected colonoscopist first observed the sigmoid colon and rectum with conventional high resolution endosopy (HRE). Then the colonoscopist changed the mode to AFI and handed to the scope to another colonoscopist who knew no information about the HRE. Then the second colonoscopist observed the sigmoid colon and rectum. Each colonoscopist separately recorded the findings. The detection rate, miss rate and procedural time were assessed in prospective manner.

Results

The detection rate of flat and depressed adenoma, but not elevated adenoma, by AFI is significantly higher than that by HRE. In less-experienced endoscopists, AFI dramatically increased the detection rate (30.3%) and reduced miss rate (0%) of colorectal adenoma in comparison to those of HRE (7.7%, 50.0%), but not for experienced endoscopists. The procedural time of HRE was significantly shorter than that of AFI.

Conclusions

AFI increased the detection rate and reduced the miss rate of flat and depressed adenomas. These advantages of AFI were limited to less-experienced endoscopists because experienced endoscopists exhibited a substantially high detection rate for colorectal adenoma with HRE.

Keywords:
Autofluorescence imaging; Colorectal adenoma; Detection rate; Flat and depressed adenoma; Less-experienced endoscopist; High-resolution colonoscope