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Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes

Sebastian Seidler1, Henning W Zimmermann1, Ralf Weiskirchen2, Christian Trautwein1 and Frank Tacke1*

Author Affiliations

1 Department of Medicine III, University Hospital, RWTH-Aachen, Germany

2 Institute of Clinical Chemistry and Pathobiochemistry, University Hospital, RWTH-Aachen, Germany

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BMC Gastroenterology 2012, 12:38  doi:10.1186/1471-230X-12-38

Published: 24 April 2012

Additional files

Additional file 1:

Figure S1. Frequencies of circulating monocytes and monocyte subsets are elevated in chronic liver disease (CLD). (A) The frequencies of total monocytes (defined as CD14+ cells) and monocyte subpopulations were measured by FACS analysis. The amount of circulating monocytes relative to all peripheral blood mononuclear cells (PBMC) was significantly higher (***p < 0.001) in patients with CLD than in healthy controls. Single values and median are depicted. (B) Absolute numbers of circulating monocytes differ between controls and patients with CLD (*p < 0.05). (C-D) Absolute counts of circulating ‘classical’ CD14++CD16- (C) and ‘non-classical’ CD14 + CD16+ (D) monocyte subsets are significantly augmented in patients with CLD (*p < 0.05 and **p < 0.01, respectively).

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