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Open Access Research article

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

Hiroshi Iida1, Masahiko Inamori12*, Tetsuro Fujii1, Yusuke Sekino1, Hiroki Endo1, Kunihiro Hosono1, Takashi Nonaka1, Tomoko Koide1, Hirokazu Takahashi1, Masato Yoneda1, Ayumu Goto1, Yasunobu Abe1, Noritoshi Kobayashi1, Hiroyuki Kirikoshi1, Kensuke Kubota1, Satoru Saito1, Eiji Gotoh3, Shin Maeda1 and Atsushi Nakajima1

Author Affiliations

1 Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan

2 Office of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan

3 Department of Medical Education, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan

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BMC Gastroenterology 2012, 12:25  doi:10.1186/1471-230X-12-25

Published: 26 March 2012

Abstract

Background

The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.

Methods

Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.

Results

The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).

Conclusions

In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.

Keywords:
Intragastric acidity; Omeprazole; Mosapride